激素联合小剂量丙种球蛋白治疗慢性格林-巴利综合征患者的疗效分析  

Effect analysis of methylprednisolone combined with small dose gamma-globulins in the treatment on chronic Guillain-Barre syndrome patients

作　　者：江利敏[1] 

机构地区：[1]河南中医学院第一附属医院神经内科,郑州450003

出　　处：《中华脑科疾病与康复杂志（电子版）》2012年第1期49-52,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：目的探讨甲基强的松龙联合小剂量丙种球蛋白治疗慢性格林-巴利综合征的临床疗效。方法将河南中医学院第一附属医院收治的64例慢性格林-巴利综合征患者随机分为治疗组32例和对照组32例,两组患者均给予维生素B1、甲钴胺等常规药物,治疗组予以甲基强的松龙联合小剂量丙种球蛋白(0.2 g·kg-1·d-1)治疗,对照组采用甲基强的松龙(500 mg/d)递减治疗,治疗4周后比较两组的治疗效果。统计学方法:两组有效率比较采用χ2检验,起效时间及住院天数的组间比较采用t检验。结果治疗组29例有效,总有效率为90.6%,起效时间为(3.83±1.35)d,平均住院时间为(22.03±3.05)d,对照组20例有效,总有效率为62.5%,起效时间为(6.90±1.42)d,平均住院时间为(40.15±5.16)d,两组各项数据比较差异均有统计学意义(χ2=7.05,t=2.361、2.962,P值均<0.05)。结论甲基强的松龙联合小剂量丙种球蛋白治疗慢性格林-巴利综合征较单用甲基强的松龙起效快,疗效显著,且能缩短平均住院时间,无严重不良反应,值得推广。Objective To observe the therapeutic effect of methylprednisolone combined with small dose gamma-globulins on chronic Guillain-Barre syndrome. Methods Sixty-four patients with chronic Guillain-Barre syndrome treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine were randomly divided into two groups（ treatment group and control group）. Both groups were given basical treatment of chronic Guillain-Barre syndrome such as VitBl and Mecobalamin. Methylprednisolone combined with small dose gamma-globulins （0. 2 g ·kg^-1·d^-1） were given on treatment group, methylprednisolon （500 mg/d）alone was given on control group in the early days and then was given the decrements regularly. The clinical treatment outcomes were evaluated on both groups. Statistical methods ： chi- square test was used in the comparison of clinical effective rates ; T-test was used in the the comparisons of the occurrence time of effectiveness and the length of stay respectively. Results The effective cases in treatment group were 29, the total effective rate was 90.6%, the treatment effect appeard in （3.83± 1.35 ） days, the average length of stay in the hospital was （22.03± 3.05 ） days. The effective cases in control group were 20, the total effective rate was 62.5 %, the treatment effect appeard in （6.90± 1.42） days, the average length of stay in the hospital was （40. 15 ±5.16） days. The differences were statistically significant results （X2 = 7.05, t = 2. 361 and 2. 962 respectively, P 〈 0. 05 ）. Conclusions The effect of small dose gammaglobulins combined with methylprednisolone in the treatment of chronic Guillian-Barre syndrome shows up fast. The curative effect is better than that of methylprednisolon alone. The combination therapy can reduce the average length of hospital stay, and no serious adverse effects, is worth further extension.

关 键 词：格林-巴利综合征 慢性 丙种球蛋白类 治疗效果 

分 类 号：R745.43[医药卫生—神经病学与精神病学]