mTORC2调节细胞骨架的信号通路  

Signaling Pathways of mTORC2 Regulate Actin Cytoskeleton

作　　者：陈银涛[1] 于秉治[2] 武迪迪[2] 

机构地区：[1]中国医科大学临床医学院,沈阳110001 [2]中国医科大学基础医学院生化与分子生物学教研室,沈阳110001

出　　处：《中国细胞生物学学报》2012年第10期1030-1035,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.81070489)资助项目~~

摘　　要：近几年来,关于哺乳动物雷帕霉素靶(mammalian target of rapamycin,mTOR)在各种哺乳动物细胞中调节肌动蛋白微丝极化及肌球蛋白微丝网形成的研究一直在不断地取得新的进展。尽管到目前为止,包括mTORC2上游和下游在内的相关的调控路径还未明确,但是因为mTORC的生物学多样性,使其成为了当今生物学研究的焦点之一。基于长久以来特别是近五年对mTORC2的研究,在涉及细胞运动迁移、增殖分化、蛋白质合成、凋亡及自噬等生物学功能的研究中,一些重要的下游相关调控分子和蛋白相继被发现,比如P-Rex1/2、Rho家族GTPases、PKC、cAMP、p27Kip1等。该综述着重总结了mTORC2实现这些生物学功能所可能通过的四条路径。当然,仍然需要大量的实验数据和研究证据进一步地证实和完善这些已经发现的可能存在的路径。Researches about the role of the target of rapamycin complex 2 （mTORC2） during various mammalian cells have always been progressing, a process that is mediated through the polarization of actin and myosin filament networks. The concrete routes of upstream and downstream regulatory molecules of mTORC2 are still undetermined. Based on large experiment data upon the filed from recent years, we can roughly conclude four routes by which mTORC2 regulate actin cytoskeleton to fulfill motility, adhesion, fission and some other biological functions. Some important proteins or molecules associated with the process have been found successively. They are P-Rexl/2, Rho family GTPase, PKC, cAMP, p27kipl and so on. This review will try to draw roughly the routes map with the related proteins or molecules that have been known. But all remain to be identified by more evidences and experiments.

关 键 词：mTORC2 细胞骨架 微丝 肌动蛋白 信号通路 

分 类 号：R363[医药卫生—病理学]