日本青鳉2种WNT4基因的克隆及鉴定(英文)  

MOLECULAR CLONING AND IDENTIFICATION OF TWO WNT4 GENES FROM THE MEDAKA (ORYZIAS LATIPES)

作　　者：李建中[1,2] 刘琼[1] 王德寿 周林燕 酒井章依 长滨嘉孝 

机构地区：[1]湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室,长沙410081 [2]日本国立基础生物学研究所生殖生物学实验室

出　　处：《水生生物学报》2012年第5期983-986,共4页Acta Hydrobiologica Sinica

基　　金：Project of National Natural Science Foundation of China(Grant No.31072199);the program of Japan Society for the Promotion of Science(JSPS)

摘　　要：Wingless-type MMTV integration site family,member 4(WNT4) is a critical signaling molecule,regulating cell-cell interactions,proliferation,differentiation,migration,and gene activation [1,2].It is a highly conserved gene with mammals and has multiple roles in organogenesis and homeeostasis,and it has special importance in the sexual differentiation of the ovary [3 - 6].Wingless-type MMTV integration site family, member 4 （WNT4） is a critical signaling molecule, regulating cell-cell interactions, proliferation, differentiation, migration, and gene activation. It is a highly conserved gene with mammals and has multiple roles in organogenesis and homeeostasis, and it has special importance in the sexual differentiation of the ovaryt3-61. WNT4-mutant females show a lack of mullerian ducts, an increase in ectopically steroidogenic cell migration,

关 键 词：WNT4基因 克隆 系统进化分析 同线性分析 青鳉 

分 类 号：Q781[生物学—分子生物学]