铝碳酸镁治疗胆囊切除术后胆汁反流性胃炎的研究  

Efficacy of Home Made Hydrotalcite in Treating Bile Reflux Gastritis after Cholecystectomy

作　　者：赵新华[1] 冯琦[1] 冯凯祥[1] 章静[1] 罗玉君[1] 黄小丽[1] 

机构地区：[1]绵阳市中心医院消化内科,四川绵阳621000

出　　处：《中国医药指南》2012年第28期39-41,共3页Guide of China Medicine

摘　　要：目的评估国产铝碳酸镁(威地美)和进口同类产品(达喜)治疗胆囊切除术后胆汁反流性胃炎的疗效及安全性。方法 60例伴有腹痛、烧灼感、腹胀、口苦等症状患者由胃镜诊断为胆汁反流性胃炎。患者分为3组,A组(威地美)20例,给予国产铝碳酸镁1.0g,每天3次;B组(达喜)20例,给予进口产品1.0g,每天3次,C组观察未治疗组20,给予随访观察。疗程均为8周。治疗前、后,均观察治疗前后临床症状积分、胃镜下改变、组织学积分以及药物不良反应。结果与观察无治疗组相比,国产铝碳酸镁和进口铝碳酸镁均是治疗胆囊切除术后胆汁反流性胃炎的有效药物,两组间疗效无显著差异。两组均未见明显的不良反应。结论国产铝碳酸镁可结合胃内胆汁,有效缓解胆汁反流性胃炎症状,是治疗胆囊切除术后胆汁反流性胃炎安全、有效的药物。Objective To evaluate the efficacy and safety of two kinds of hydrotalcite,Weidimei and Talcid,in patients with bile reflux gastritis after Cholecystectomy.Methods Postcholecystectomy patients with bile reflux gastritis confirmed by endoscopy were randomly assigned to one of three eight-week treatments,group A（Weidimei）,group B（Talcid） and group C（observation）.Endoscopy was repeated in all patients after treatment.Dyspeptic symptoms of abdominal pain,bloating,heartburn,bitter taste,endoscopic and histological finding were evaluated before and after treatment.Results Weidimei and Talcid therapies were both able to significantly reduce epigastric pain,heartburn,bloating and bitter taste.Endoscopic/histological signs were lower in both treatment groups compared to the observation group.Conclusion Two kinds of hydrotalcite can combine in—tragastric bile and is effective and safe in the treatment of bile reflux gastritis after Cholecystectomy.

关 键 词：铝碳酸镁 胆囊切除术后 胆汁反流性胃炎 

分 类 号：R573.3[医药卫生—消化系统]