雌酮诱发大白鼠垂体腺瘤动物模型的研究  

Estron-induced hyperplasia and neoplasia in the rat anterior pituitary gland

作　　者：薛毅珑[1] 段国升[1] 张灿元[1] 徐雅萍[1] 王鲁宁[2] 刘泽艳[2] 

机构地区：[1]中国人民解放军进修学院神经外科 [2]中国人民解放军进修学院神经病理室

出　　处：《军医进修学院学报》1990年第3期241-245,共5页Academic Journal of Pla Postgraduate Medical School

摘　　要：本实验给97只不同性别的F344和Wistar大白鼠投以不同剂量的雌酮,用药后30、45和60天时,分别观察脑垂体重量及组织学变化。另24只大鼠作为正常对照组。结果表明,用药组大鼠脑垂体重量非常明显地高于对照组,脑垂体腺组织结构亦明显发生变化,其中,34％鼠呈肿瘤性改变,46.4％鼠呈增生性改变。提示雌酮可有效地诱发脑垂体腺瘤。这种变化在用药后45天时达高峰。而本实验所用的两种剂量雌酮,其诱发脑垂体瘤的效果无明显差异。本研究结果还表明,雌酮诱发脑垂体腺瘤的作用中,存在着大鼠种属差异性,F344鼠较Wistar鼠更为敏感。而大鼠的性别及是否去势对其无明显影响。这种雌激素诱发的大鼠垂体腺瘤,可为研究人类脑垂体催乳素瘤的发病机理和治疗方法,提供一个简便易行、需时较短并重复性较好的动物模型。Different doses of estron (El) were administered to 97 F344 and wistar rats. After 30, 45 and 60 days, the weight and histological change in the pituitary gland were observed. 24 rats were used as a control group. Prolonged administration of El resulted in weight increase and hyperplasia or neoplasia in the pituitary gland. The weight of pituitary gland was significantly increased than that in control rats(P<0.01). Histological study showed that 34% rats revealed neoplasia and 46.% revealed hyperplaia in pituitary glands, These changes were most significant during the period of 45 days after El administration. There was no significant difference in the incidence of neoplasia between two El dose groups. There was significant difference between F344 and Wistar rats with El evoking pituitary tumor. But, there was no significant difference between male and female rats and between ovariectomized rats and not ovariectomized rats. These data indicate that the El-induced pituitary adenoma may be a good model for human prolactinomas that might be utilized for study of the mechanism and treatment of pituitary ademoma.

关 键 词：垂体肿瘤 腺瘤 垂体腺瘤 雌激素类 动物实验 

分 类 号：R736.4[医药卫生—肿瘤]