中国人谷胱甘肽-S-转移酶M1和T1基因多态性与原发性肝细胞癌的易感性  

Study of the relationship between glutathione S-transferase genetic polymorphisms MI and T1 and susceptibility to primary liver cancer in Chinese： a meta-analysis

作　　者：肖遥[1] 马建忠[1] 

机构地区：[1]中国医科大学基础医学院数学教研室,沈阳110001

出　　处：《中华肝脏病杂志》2012年第10期774-779,共6页Chinese Journal of Hepatology

摘　　要：目的探讨中国人群谷胱甘肽-S-转移酶（GST）M1和T1基因多态性与原发性肝细胞癌遗传易感性的关系。方法通过检索PubMed和中国知网等数据库中的谷胱甘肽-S-转移酶基因多态性与原发性肝细胞癌的25篇文献，针对累计病例2788例和正常对照5548例进行Meta分析和关联性研究。对数据进行皮尔逊x2检验和异质性检验。结果GSTM1、GSTT1空白基因型与原发性肝细胞癌易感性有统计学意义，病例对照的皮尔逊x2检验P值分别是1．8×10^-11和4．6×10^-11，比值比（OR值，95％CI）分别为1．67（1．39～2．01）和1．59（1．29～1．96）。GSTM1和GSTT1的交叉分析，两者均为空白基因型的OR值（95％CI）为3．34（2．23～5．00），明显高于GSTM1和GSTT1中有一个空白基因型的OR值，相对易感性更大，两者至少有一个空白基因型比两者均为非空白基因型能提高原发肝细胞癌发病的危险性，OR值（95％CI）是2．52（1．87～3．38）。结论谷胱甘肽-S-转移酶GSTM1、GSTT1的空白基因型分别是中国人群原发性肝细胞癌的易感因素，并且GSTM1和GSTT1两者联合对原发性肝癌有协同易感作用。Objective To study the association of genetic polymorphism of glutathione S-transferase （GSTM1 and GSTT1） with susceptibility to primary liver cancer in Chinese. Methods Literature search of the PubMed, Chinese National Knowledge Infrastructure, and ISI Web of Science databases identified 25 relevant case-control studies of glutathione S-transferase genetic polymorphisms and primary liver cancer, representing a total of 2788 cases and 5548 controls. The extracted data was applied to the RevMan v4.2 software for meta-analysis. Data with significant heterogeneity was assessed by the fixed effects model, otherwise a random effects model was applied. Pooled odds ratios （ORs） with 95% confidence intervals （CIs） were calculated. Results The correlation between the GSTM1 and GSTT1 null genotypes and susceptibility to primary liver cancer showed statistical significance （cases： P = 1.8 × 10^-11 and controls： P = 4.6 × 10^-11; Pearson＇s Chi-squared test）. The OR value for GSTM1 was 1.67 （95% CI： 1.39-2.01） and for GSTT1 was 1.59 （95% CI： 1.26-1.96）. In the GSTM1-GSTT1 interaction analysis, both GSTM1 and GSTT1 were null genotypes with OR = 3.34 （95% CI： 2.23-5.00）, which was higher than the null genotype for either one of them alone and which indicated higher relative susceptibility. Compared with individuals for whom both GSTM1 and GSTT1 were non-null genotypes, the presence of at least one null genotype showed higher risk of primary liver cancer. Conclusion The null genotypes ofglutathione S-transferase genetic polymorphisms GSTM 1 and GSTT 1 are risk factors for primary liver cancer respectively, and their associated risk is increased when both are present.

关 键 词：癌 肝细胞 多态性 单核苷酸 谷胱甘肽 Meta分析 

分 类 号：R735.7[医药卫生—肿瘤]