姜黄素联合舒尼替尼治疗人786-0肾癌裸鼠移植瘤  

Experimental Study of Treatment Effect of Curcumin and Sunitinib on Transplanted Renal Clear Cell Carcinoma in Nude Mice

作　　者：田大伟[1] 陈业刚[2] 刘鹏[2] 汤洋[1] 王建民[1] 韩瑞发[1] 

机构地区：[1]天津医科大学第二医院泌尿外科,天津300211 [2]天津市南开医院,天津300100

出　　处：《中国中西医结合外科杂志》2012年第5期469-472,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探讨姜黄素联合舒尼替尼对抑制人肾癌细胞系786-0裸鼠移植瘤生长有无增效作用。方法:将32只人肾细胞癌裸鼠随机分为4组,阴性对照组以0.9%生理盐水0.2mL腹腔注射,舒尼替尼组以舒尼替尼40mg/kg腹腔注射,姜黄素组以姜黄素100mg/kg腹腔注射,研究组以舒尼替尼联合姜黄素腹腔注射。结果:研究组较其他3组具有更强的抑瘤作用,远期效果高于舒尼替尼组(P<0.05);研究组比舒尼替尼组抗血管增殖作用更加明显(P<0.01);凋亡指数明显高于其他3组(P<0.05)。结论:姜黄素联合舒尼替尼抑瘤作用明显强于单独应用舒尼替尼或姜黄素。Objective grafted To tumor growth of human study whether curcumin could potentiate renal clear cell carcinoma in nude mice the antitumor effect of sunitinib on xeno- Methods Thirty two nude mice bear- ing human renal clear cell 786-0 xenografted tumor were randomly divided into 4 groups （ n=8 in each group ）： control group （ 0.2 rnL 0.9%NS, intraperitoneal injection）, sunitinib group （40 mg/kg, intraperitoneal injection）, curcumin group （100 mg/kg, intraperitoneal injection）, and the combination group of curcumin and sunitinib. Results Compared with the other three groups, the combination group of curcumin and sunitinib demonstrated significant tumor growth inhibition （P 〈 0.05）, the combination group could significantly slow down tumor growth, especially for a forward treatment effect than used sunitinib group alone（P 〈 0.05）. The cell apoptosis in- dex （TUNEL） showed that combination group apoptosis index was significantly higher than those in the other three groups （P 〈 0.05）. Combined treatment group showed more obvious action against vascular proliferation function than contrast used sunitinib alone （P 〈 0.01）. Conclusion The combination group of curcumin and sunitinib leads to suppression of tumor obviously better than used sunitinib or curcumin alone, therefore curcum- in may become sunitinib sensitizers and improve the treatment effect.

关 键 词：姜黄素 舒尼替尼 肾癌 裸鼠 移植瘤 

分 类 号：Q95-33[生物学—动物学] R737.11[医药卫生—肿瘤]