多囊卵巢综合征父/母系亲属遗传表型的分析  

Analysis of phenogenetic correlation of polycystic ovary syndrome from agnate and maternal relatives

作　　者：李晓红[1] 李国屏[1] 陈湘梅[1] 易红[1] 李瑾[1] 

机构地区：[1]深圳市宝安区妇幼保健院生殖健康科,广东518133

出　　处：《生殖医学杂志》2012年第5期443-446,共4页Journal of Reproductive Medicine

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者的发病与其父系、母系一、二级亲属遗传表型的相关性,为该病的预测和预防提供理论依据。方法采用家系调查量表,收集2004年10月～2011年5月在本院生殖健康科门诊就诊882例PCOS患者的父系、母系一、二级亲属的临床资料为研究组及同期660例月经规律、B超示双侧卵巢无多囊改变的育龄期妇女父系、母系一、二级亲属的临床资料为对照组,比较肥胖、高血压、糖尿病、月经稀发在父系、母系一、二级亲属间的发生情况并进行统计学分析。结果研究组父系、母系一、二级亲属中,高血压、糖尿病、肥胖、月经稀发的发生情况显著高于对照组(P<0.01),母系组一、二级亲属肥胖、高血压、糖尿病、月经稀发总的发生率为63.2%(557/882),而父系组总的发生率为49.2%(434/882),经卡方检验发现这两者具有显著统计学差异(x^2=34.838,P<0.01),但母系组一、二级亲属高血压、糖尿病的发生率与父系组无显著性差异(P>0.05);母系组肥胖的发生显著高于父系组(P<0.05);母系组月经稀发的发生率显著高于父系组(P<0.01)。结论 PCOS患者与母系亲属遗传表型关系密切,母系亲属肥胖、月经稀发可能是后代患PCOS的主要遗传表型,精神心理因素在该病的发生中起重要作用,是其危险因素。Objective： To investigate the phenogenetic correlation of polycystic ovary syndrome （PCOS） in agnate/maternal first-degree and second-degree relatives. Methods： A total of 882 patients with PCOS who attended to the reproductive health clinic of Bao＇an Maternal and Children＇s Health Hospital from Oct. 2004 to May 2011 were investigated. The frequency rate of some biomedical parameters both in agnate and maternal first-degree and second-degree relatives was compared. The agnate and maternal first-degree and second-degree relatives of infertile women with normal menstruation cycle and without PCOS were as control group. The data of obesity, hypertension, diabetes mellitus, abnormal menstruation, oligomenorrhea and amenorrhea were recorded and compared. Results： In agnate and maternal first-degree and second-degree relatives, the accidence of obesity, hypertension, diabetes mellitus, oligomenorrhea in patients with PCOS were higher than those in patients without PCOS （P 〈 0. 01）. The total incidence of obesity, hypertension, diabetes mellitus and oligomenorrhea was 63.2% （557/882）in maternal first-degree and second-degree relatives of patients with PCOS, and 49.2%（434/882）in the agnate relatives. It found a significant difference after X2 test （P〈 0.01）. The frequency rate of hypertension, diabetes mellitus in agnate first-degree and second-degree relatives was not significantly different with the maternal relatives （P〉0.05）. However, the incidences of obesity and oligomenorrhea in maternal were significantly higher than those in the agnate （P〈0.05 ＆ P〈0. 01）. Conclusions： PCOS is correlative with genetic phenotype of maternal relatives. Obesity and oligomenorrhea in the maternal relatives may be the major genetic factors for suffering PCOS in offspring. The psychological factor is another risk and important factor.

关 键 词：多囊卵巢综合征 遗传表型 肥胖 高血压 糖尿病 月经稀发 

分 类 号：R[医药卫生]