肿瘤发生的表观遗传学:进展与临床意义  

Epigenetics in tumorigenesis:advances and clinical implications

作　　者：王先火[1,2] 赵秀娟[3] 邱立华[1,2] 王华庆[1,2] 王玺[1,2,3,4] 

机构地区：[1]天津市肿瘤医院 [2]天津医科大学附属肿瘤医院淋巴瘤科,天津300060 [3]天津医科大学基础医学院细胞生物学系,天津300070 [4]Dana Farber Cancer Institute,Harvard Medical School,Boston

出　　处：《北京大学学报（医学版）》2012年第5期701-707,共7页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(81171899)资助~~

摘　　要：表观遗传（epigenetics）指所有不通过DNA序列改变就能影响基因表达（从而决定细胞乃至个体表型）的、可遗传的（即可伴随细胞分裂传递下去）调控方式,包括DNA甲基化、组蛋白修饰、染色质重塑、miRNA、朊病毒等。表观遗传调控在干细胞自我更新、定向分化、器官发育等生命过程中起着至关重要的作用：Cancer is a leading cause of death worldwide and the total number of cases globally keeps increasing.For many years,cancer has been thought to be caused by a series of DNA sequence alterations and thus is thought to be a ＂genetic＂disease.However,studies in the last decade,including the large-scale cancer genomics projects,have highlighted the rising importance of epigenetic regulation in cancer.Here,we review recent advances in understanding how chromatin-based epigenetic regulation participates in tumorigenesis and discuss the growing implications of these advances for developing novel strategies to prevent,diagnose,as well as treat cancer.

关 键 词：表观遗传 肿瘤 DNA甲基化 组蛋白修饰 染色质组装和分解 

分 类 号：R730.2[医药卫生—肿瘤]