脑胶质瘤的^1H磁共振波谱特点及临床意义  

Gliomas findings on proton magnetic resonane spectroscopy imaging and its clinical application

作　　者：吴涛[1] 刘胜[1] 王诚[1] 高玉红[1] 韩宗利[1] 

机构地区：[1]北京大学深圳医院神经外科,深圳518036

出　　处：《中国临床神经外科杂志》2012年第10期625-626,629,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨人脑胶质瘤质子磁共振波谱(1HMRS)的特点及临床意义。方法 22例脑胶质瘤患者术前行MRI检查的同时作1HMRS分析,并以20例对侧正常的相应部位作为自身对照,比较N-乙酰门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)和乳酸(Lac)以及Cho/Cr、NAA/Cr、NAA/Cho比值的变化。结果与对照脑区比,脑胶质瘤在1HMRS上均表现为明显增高的Cho峰(P<0.01),NAA、Cr峰下降或消失(P<0.05),Cho/Cr比值升高,NAA/Cr比值降低(P<0.05);它们的变化并与肿瘤不同病理级别密切相关,其差异具有显著性(P<0.05)。结论 1HMRS是研究脑胶质瘤物质和能量代谢的有效方法,能为脑胶质瘤的临床诊断提供帮助。Objective To investigate gliomas findings on ^1HMRS and its clinical application. Methods ^H magnetic resonane spectroscopy （^1HMRS） examination were performed in 22 patients with gliomas, of whom, 11 had WHO grades Ⅰ ～ Ⅱ, 5 WHO grades Ⅲ astrocytomas, and 6 glioblastomas. The contralateral normal hemispheres of 20 patients served as control group. Results The top of choline （cho） significantly increased and the tops of N-acetyl-asparate （NAA） and creatine （Cr） significantly decreased on ~HMRS in the gliomas compared to those in the control group （P〈0.05）. The ratio of Cho/Cr was significantly higher, and the ratios of NAA/Cr and NAA/ Cho were significantly lower in the gliomas than those in the control group （P〈0.01）. Conclusions ^1HMRS is an effective method to study substance and energetic metabolism in the gliomas, and helpful to the diagnosis of the giiomas.

关 键 词：脑胶质瘤 质子磁共振波谱 

分 类 号：R739[医药卫生—肿瘤] R445[医药卫生—临床医学]