肠型脂肪酸结合蛋白检测胃肠肿瘤手术患者肠黏膜屏障功能改变  

Role of Intestinal Fatty Acid Binding Protein in Evaluating Intestinal Mucosal Barrier Function in Patients with Gastrointestinal Cancer Surgery

作　　者：权斌[1,2] 吕孝鹏[1,2] 谢志远[1,2] 

机构地区：[1]东南大学附属徐州医院 [2]徐州市中心医院胃肠外科,江苏省徐州市221009

出　　处：《中华全科医学》2012年第11期1695-1695,1744,共2页Chinese Journal of General Practice

摘　　要：目的研究肠型脂肪酸结合蛋白在检测胃肠肿瘤手术患者肠黏膜屏障功能改变中的应用价值。方法前瞻、随机选取接受胃肠肿瘤手术的患者30例,于术前1 h,术后2 h,术后12 h,术后24 h,术后48 h,术后72 h,采取血清检测I-FABP含量的变化,30例接受乳腺、甲状腺手术患者作为对照。结果实验组患者术后2 h开始,I-FABP即明显升高(P<0.05),至术后12 h升至最高点,至术后48 h患者I-FABP水平基本恢复至术前水平,而接受甲状腺、乳腺手术的患者术后虽呈现升高趋势但改变并不明显(P>0.05)。结论肠型脂肪酸结合蛋白是胃肠肿瘤手术后肠黏膜屏障功能改变的早期、敏感性指标。Objective To study the use of intestinal fatty acid binding protein（I-FABP） in evaluating intestinal mucosal barrier function in patients with gastrointestinal cancer surgery. Methods Thirty patients undergoing the gastrointestinal cancer surgery were selected randomly and prospectively, and 30 patients undergoing breast or thyroid surgery were as control. The serum I-FABP levels were detected at the time points：l h before the operation,2 h,12 h,24 h,48 h and 72 h after the operation. Results In the experimental group ,the I-FABP level began to increase obviously at 2 h after the operation（ P 〈 0.05 ） , and reached the high- est point at 12 h after the operation. At 48 h after the operation, the I-FABP level restored to the preoperative level. In the control group,the I-FABP level did not changed significantly （P 〉 O. 05 ）. Conclusion I-FABP is an early and sensitive indicator of change of intestinal mucosal function after zastrointestinal cancer surgery.

关 键 词：肠型脂肪酸结合蛋白 胃肠肿瘤 手术 肠黏膜屏障 

分 类 号：R735[医药卫生—肿瘤] R730.5[医药卫生—临床医学]