乙型肝炎病毒相关性肝癌发生的分子机制研究进展  

Molecular mechanism in HBV infection related hepatocellular carcinoma

作　　者：颜见[1] 姚志成[1] 邓美海[1] 

机构地区：[1]中山大学附属第三医院肝胆外科,广州510630

出　　处：《中华普通外科学文献（电子版）》2012年第5期50-54,共5页Chinese Archives of General Surgery(Electronic Edition)

基　　金：国家青年自然科学基金项目(81000177);广东省科技计划项目(2010B031600215)

摘　　要：原发性肝癌是常见的恶性肿瘤之一,乙肝病毒(hepatitis B virus,HBV)感染是原发性肝癌发生和发展的最主要的危险因素之一,因此深入研究乙肝相关性肝癌的发病机制成为一项长期而艰巨的任务,为肝癌的预防及合理治疗提供依据。本文将近年来乙肝相关性肝癌的分子机制做如下综述。Hepatocellular carcinoma is one of the most common malignant tumors. It has been proved that HBV infection plays a crucial role in tumorigenesis and development of hepatocellular carcinoma, so it is a long-term and formidable task for us to lucubrate the pathogenesis of HBV-related HCC, which will provide the basis for prevention and reasonable treatment for HCC. This article has comprehensively reviewed the molecular mechanism of HBV-related HCC in recent years.

关 键 词：HBV 原癌基因 抑癌基因 细胞因子 HBX蛋白 

分 类 号：R735.7[医药卫生—肿瘤]