肿节风配方颗粒防治放射性口干的临床观察  

Clinical Observation on Sarcandra Glabra Compatible Granule in Prevention and Treatment of Xerostomia Induced by Radiation

作　　者：吴芳[1] 王仁生[1] 韦波[2] 刘文其[1] 张勇[1] 杜清华[1] 吕君[1] 

机构地区：[1]广西医科大学第一附属医院放疗科,南宁市530021 [2]广西医科大学流行病学教研室,南宁市530021

出　　处：《广西医学》2012年第11期1459-1462,共4页Guangxi Medical Journal

基　　金：广西科学研究与技术开发计划项目(桂科攻0992003A-4);广西医药卫生科研课题(桂卫重200911)

摘　　要：目的观察肿节风配方颗粒对鼻咽癌患者放疗所致口干的临床疗效。方法鼻咽癌患者125例,其中常规放疗组42例,常规放疗+肿节风配方颗粒组43例,调强放疗组40例。肿节风配方颗粒4 g/次,2次/d,放疗前3 d开始口服至放疗结束。3组均给予诱导化疗及同步放化疗,化疗方案按PF方案。检测3组放疗前、放疗结束、放疗后3、6、12、18和24个月唾液分泌量,并观察口干分级情况。结果 3组放疗前唾液分泌量差异无统计学意义(P>0.05),放疗结束时及放疗后3、6、12、18和24个月唾液分泌量比较差异有统计学意义(P<0.05),常规放疗+肿节风组、调强放疗组明显多于常规放疗组(P<0.05),常规放疗+肿节风组与调强放疗组差异无统计学意义(P>0.05)。3组口干程度在放疗结束及放疗后3、6、12、18和24个月差异有统计学意义(P<0.05),常规放疗组严重于常规放疗+肿节风组、调强放疗组(P<0.05),常规放疗+肿节风组与调强放疗组差异无统计学意义(P>0.05)。结论肿节风配方颗粒可减轻因常规放化导致口干的严重程度,促进腮腺功能的恢复。Objective To observe the clinical effect of Sarcandra glabra compatible granule against xerostomia induced by radiotherapy in nasopharyngeal carcinoma （NPC）. Methods One hundred and twenty five patients with NPC were divided into three groups：conventional radiotherapy（CRT） group （42 cases）, CRT combined with Sarcandra glabra compatible granule group （43 cases） and intensity-modulated radiation therapy （IMRT） group （40 cases）. The patients in CRT combined with Sarcandra glabra compatible granule group were treated with oral Sarcandra glabra compatible granule three days before radiotherapy, 4 g once for twice a day, until the end of radiotherapy. All the patients in the three groups received induction chemoradiotherapy and concurrent radiotherapy and chemotherapy, the chemotherapy regimen was PF. Salivary secretion was examined before radiotherapy, at the end of radiotherapy, at 3 months,6 months, 12 months, 18 months and 24 months after radiotherapy, respectively. Simultaneously, xerostomia of the patients was observed. Results There was no significant difference in salivary secretion before radiotherapy among three groups （P 〉 0.05 ）. Salivary secretion showed significant difference at the end of radiotherapy, at 3 months, 6 months,12 months, 18 months and 24 months after radiotherapy among three groups （P 〈 0.05 ）, which in CRT combined with Sarcandra glabra compatible granule group and IMRT group were obviously higher than that in CRT group（P 〈 0. 05 ） ; No significant difference was found between CRT combined with Sarcandra glabra compatible granule group and IMRT group （P 〉 0.05 ）. There was significant difference in xerostomia at the end of radiotherapy, at 3 months,6 months, 12 months, 18 months and 24 months after radiotherapy among three groups （P 〈 0.05 ）. The extend of xerostomia in CRT combined with Sarcandra glabra compatible granule group and IMRT group were obviously slighter than that in CRT group （P 〈 0.05 ）, no significant difference

关 键 词：鼻咽肿瘤 肿节风 放射治疗 口干 

分 类 号：R739.6[医药卫生—肿瘤]