低氧诱导因子1与脑出血的研究进展  

Research Progress of Hypoxia Inducible Factor-1 and Intracerebral Hemorrhage

作　　者：张红波[1] 丰宏林[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,哈尔滨150001

出　　处：《医学综述》2012年第18期2956-2958,共3页Medical Recapitulate

摘　　要：低氧诱导因子1(HIF-1)是缺氧环境的重要调节因子,对低氧反应性基因的转录有调控作用,并参与低氧反应的信号转导过程。轻度缺氧时,HIF-1产生缺氧耐受性,发挥神经保护作用;长期重度缺氧时,诱导神经细胞凋亡,具有神经毒性作用。最近的研究表明,脑出血后随着局部脑血流量下降,HIF-1表达增加。现就HIF-1概况、低氧活性调节以及与脑出血的可能关系进行综述。Hypoxia inducible factor-1（HIF-1）is an important regulatory factor in a hypoxic environment,and it has regulatory effect on transcription of hypoxia response gene,and participates in signal transduction processes of hypoxia response.HIF-1 induces hypoxia tolerance and exerts neuroprotective effect during mild hypoxia.It induces neuronal apoptosis and has a neurotoxic effect during prolonged severe hypoxia.Recent studies have suggested that,after cerebral hemorrhage,HIF-1 expression increases with regional cerebral blood flow in perihematoma being reduced.Here is to make a review on the general situation of HIF-1,hypoxia activity regulation and the possible correlation with intracerebral hemorrhage.

关 键 词：低氧诱导因子1 脑水肿 脑出血 血管内皮生长因子 

分 类 号：R743[医药卫生—神经病学与精神病学]