新疆哈萨克族人群谷胱甘肽S转移酶M1、T1基因多态性  

Frequencies of glutathione S-transferase(GSTs) M1,T1(GSTM1,GSTT1) polymorphisms in Xinjiang Kazakh population

作　　者：凌敏 安海燕 苟安栓 荣艳 牛灵 白杰[2] 

机构地区：[1]新疆自治区人民医院呼吸二科,新疆乌鲁木齐830001 [2]新疆大学研究生院,新疆乌鲁木齐830000

出　　处：《临床肺科杂志》2012年第11期1943-1945,共3页Journal of Clinical Pulmonary Medicine

基　　金：中华医学会慢性呼吸道疾病专项基金(2007年)(编号07010160024)

摘　　要：目的探讨谷胱甘肽S转移酶M1、T1基因多态性在新疆哈萨克族人群中分布的特点。方法通过多重聚合酶链反应对新疆哈萨克族264例个体GSTM1、GSTT1基因型进行检测。结果 GSTM1、GSTT1基因缺失型在新疆哈萨克族人群中频率分别为47%及36.4%,同时为GSTM1、GSTT1基因缺失型的频率为20.5%。结论新疆哈萨克族人群GSTM1、GSTT1基因多态性与汉族及其他少数民族存在一定差异。Objective To investigate the distribution characteristics of glutathione S-transferase （GSTs） M1, TI （GSTM1, GSTT1 ） polymorphisms in Xinjiang Kazakh population and provide the relevant data for studying the genotype of Kazakh population. Methods GSTM1, GSTT1 genotype of 264 individuals in Xinjiang Kazakh population were detected. Genotype was performed using mul- tiplex polymerase chain react. Results GSTMl-null and GSTFl-null genotype frequencies were respectively 47% and 36.4% , and the frequencies with combination of GSTMI null and GSTT1 null was 20.5% in Kazakh population. Conclusion There are differences between Xinjiang Kazakh population and the Han and other ethnic minorities in （ GSTM1, GSTT1 ） polymol-phisms.

关 键 词：谷胱甘肽S转移酶 基因型 多态性 

分 类 号：R394[医药卫生—医学遗传学]