食管癌高发区60181例患者及父母、同胞食管癌和贲门癌患病情况调查  

Prevalence of esophageal and gastric cardia cancer in 60181 patients,their parents and siblings from high incidence areas in China

作　　者：郭莉[1] 宋昕[1,2] 刘亚丽[1,2] 汤萨[1] 付文静[1] 解远[1] 王青玉[1] 魏武[3] 刘宾[4] 王立东[1,2] 

机构地区：[1]郑州大学第一附属医院河南省食管癌重点开放实验室,河南郑州450052 [2]新乡医学院癌症研究中心,河南新乡453003 [3]长治医学院血液病研究所病理科,山西长治046000 [4]首都医科大学附属北京同仁医院消化内科,北京100176

出　　处：《河南大学学报（医学版）》2012年第3期210-212,共3页Journal of Henan University:Medical Science

基　　金：国家科技部863重大项目(2012AA02A503);国家自然科学基金项目(81071783);河南省卫生科技创新人才项目(3047)

摘　　要：目的通过调查食管癌高发区60 181例患者及父母、同胞食管癌和贲门癌患病情况,了解夫妻不同患病类型(双发、单发和正常)与子女发病关系,加深对食管癌遗传倾向性的认识。方法研究对象来自我们实验室食管癌和贲门癌资料库,采用卡方检验和Logistic回归方法,比较夫妻不同患病类型的发生率与其子女食管癌和贲门癌的患病风险。结果与正常夫妻相比,夫妻均为食管癌和/或贲门癌患者的子女≥2人患食管癌和贲门癌的风险升高近12倍(13.79%,1.32%,P<0.05,OR=11.867,95%CI=9.026～15.601),单发(妻)患者的子女≥2人患癌风险升高近10倍(11.93%,1.32%,P<0.05,OR=10.042,95%CI=8.357～12.067),单发(夫)患者的子女≥2人患癌风险升高近9倍(10.63%,1.32%,P<0.05,OR=8.817,95%CI=7.419～10.479)。结论夫妻癌和单发(夫/妻)癌其子女≥2人患食管癌或贲门癌的几率明显高于正常夫妻的子女,提示了遗传因素对食管癌和/或贲门癌癌变具有重要的影响。Objective To highlight the prevalence of esophageal and gastric cardia cancers（EC and GCA） in husband and wife（double patients,single patient and normal healthy couple） and their children,and to further deepen the understanding of the genetic role in esophageal and gastric cardia carcinogenesis.60 451 patients with EC and GCA and their parents and siblings were enrolled in this study.Methods All the patients′ information was from EC and GCA database in Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital of Zhengzhou University.The Chi-Square test and Logistic regression were used to evaluate the risk for EC and GCA in parents and their siblings.Results Compared with normal couples,the risk of EC or GCA increased nearly 12 folds（13.79%,1.32%,P〈0.05,OR=11.867,95%CI=9.026~15.601） in the siblings whose father and mother both had EC or GCA than in those whose father and mother were healthy.In the condition of mother or father with EC or GCA,the risk for EC or GCA in their siblings increased nearly 10 folds（11.93%,1.32%,P〈0.05,OR=10.042,95%CI=8.357~12.067） or 9 folds（10.63%,1.32%,P〈0.05,OR=8.817,95%CI=7.419~10.479） respectively.Conclusion The risk for EC or GCA increased dramatically in the siblings whose parent（s） had single or double EC or GCA,suggesting the important genetic role involved in esophageal and gastric cardia carcinogenesis.

关 键 词：食管癌 高发区 夫妻癌 遗传因素 环境因素 

分 类 号：R735.1[医药卫生—肿瘤]