Theoretical studies and industrial applications of oxidative activation of inert C-H bond by metalloporphyrin-based biomimetic catalysis  

作　　者：LIU Qiang GUO CanCheng 

机构地区：[1]Advanced Catalytic Engineering Research Center of Ministry of Education,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China

出　　处：《Science China Chemistry》2012年第10期2036-2053,共18页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (0142003, 20376018, 2890047, 29372047 , 2950041);National High-Tech Research & Development Program of China (863 Program, 2002AA321070 and 2006AA32Z467);National Key Technologies R & D Program of China (2004BA322B)

摘　　要：High costs and low catalytic efficiency of metalloporphyrins, which are an analogue of cytochrome P450 enzyme, are the bot-tlenecks in the industrialization of biomimetic hydrocarbon oxidation reactions. The basic principle and research technique of physical organic chemistry were applied to the process of biomimetic oxidation of hydrocarbon catalyzed by metalloporphyrins. This biomimetic technology could be adapted to bulk chemicals production by developing the new methods for efficient scale-up synthesis of metalloporphyrins, new pathways for molecular oxygen activation on an industrial scale and new approaches to elevate the catalytic efficiency of metalloporphyrins. This review mainly focuses on research carried out in our group.High costs and low catalytic efficiency of metalloporphyrins, which are an analogue of cytochrome P450 enzyme, are the bot-tlenecks in the industrialization of biomimetic hydrocarbon oxidation reactions. The basic principle and research technique of physical organic chemistry were applied to the process of biomimetic oxidation of hydrocarbon catalyzed by metalloporphyrins. This biomimetic technology could be adapted to bulk chemicals production by developing the new methods for efficient scale-up synthesis of metalloporphyrins, new pathways for molecular oxygen activation on an industrial scale and new approaches to elevate the catalytic efficiency of metalloporphyrins. This review mainly focuses on research carried out in our group.

关 键 词：METALLOPORPHYRIN biomimetic oxidation C-H bond activation MECHANISM CATALYSIS 

分 类 号：O621.25[理学—有机化学]