AKR1C2与Twist在胃组织中的表达及其临床病理相关性的研究  

To study AKR1 C2 and Twist expressions in various gastric tissues and the clinical pathological relations of AKR1 C2 and Twist

作　　者：吕威[1] 冯美燕[1] 宋鸿涛[1] 姜影[1] 佟丹丹[1] 李玉莲[1] 石清涛[1] 耿敬姝[1] 

机构地区：[1]哈尔滨医科大学附属第三医院病理科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2012年第5期389-393,共5页Practical Oncology Journal

基　　金：基金项目：国家自然科学基金（81071759）

摘　　要：目的探讨醛酮还原酶1C2（AKR1C2）和转录因子Twist在不同胃组织中的表达及相关性。方法应用免疫组化的方法检测AKR1C2和Twist在156例胃癌组织、31例胃不典型增生组织以及20例正常胃组织中的表达，比较两者的相关性。结果AKR1C2在20例正常胃组织中均低表达；在31例不典型增生胃组织中有25例低表达，6例高表达，差异有统计学意义；在156例恶性胃癌组织中有70例低表达，86例高表达，差异有统计学意义（P〈0．01）。Twist在20例正常胃组织中19例低表达，1例高表达；在31例不典型增生胃组织中有28例低表达，3例高表达，差异有统计学意义；在156例恶性胃癌组织中有49例低表达，107例高表达，差异有统计学意义（P〈0．01）。AKR1C2与Twist的表达在胃癌组织中具有正相关性（P〈0．01）。AKR1C2在不同胃组织中的表达差异具有统计学意义（P〈0．01）。结论AKR1C2和Twist的表达特点可作为胃癌诊断、治疗及预后的参考指标。而且AKR1C2很可能参与到上皮间质转化过程中。Objective To investigate the expressions of Aldo - Keto Reductase 1 C2 （AKR1C2） and Twist in different gastric tissues and their clinical pathological relations. Methods Immunochemical method is used to detect AKR1C2 and Twist expressions in 156 cases of gastric carcinoma,31 cases of atypical hyperplasia and 90 cases of normal gastric tissues. The correlation of the two expressions was compared. Results The expression of AKR1C2 was not detected in all 20 normal gastric tissue cases. But, Its expression was up - regulated in 6 atypi- cal hyperplasia cases from 31 and 86 gastric carcinoma cases from 156. There was statistical significance in latter （P 〈 0.01 ）. The expression of Twist was not detected in 19 normal gastric tissue cases from 20. But the expression of it was up - regulated in 3 atypical hyperplasia cases from 31 and 107 gastric carcinoma cases from 156. There was statistical significance in latter（P 〈0.01 ）. The expressions of AKR1C2 and Twist in gastric carcinoma were positively related（ P 〈 0.01 ）. The expression of AKR1 C2 in different gastric tissues has statistical signifi- cance （ P 〈 0.01 ）. Conclusion AKRIC2 and Twist could be used as bio - markers for diagnosis and prognosis of the gastric carcinoma. In addition,AKRIC2 may be involved in Epithelial -Mesenchymal Transition（EMT）.

关 键 词：胃癌 AKR1C2 TWIST 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]