18F—FDG PET—CT影像表现与非小细胞肺癌预后的关系  

The Correlation Between 18F - FDG PET - CT image and prognosis of non - small cell lung cancer

作　　者：韩波[1] 林珊[1] 珊丹[1] 杨丽姝[1] 高纯子[1] 颜莹[1] 刘园[1] 李勇[2] 林春艳[3] 于丽娟[4] 

机构地区：[1]哈尔滨医科大学附属第一医院肿瘤科二病房,哈尔滨150001 [2]哈尔滨医科大学附属第一医院PET-CT [3]哈尔滨医科大学附属第一医院免疫室 [4]哈尔滨医科大学附属第三医院PET-CT

出　　处：《实用肿瘤学杂志》2012年第5期399-404,共6页Practical Oncology Journal

基　　金：基金项目：黑龙江省教育厅科学技术研究项目资助（11551292）

摘　　要：目的探讨非小细胞肺癌（non—small cell lung cancer，NSCLC）2-deoxy-18F—fluoro—D—glucose（18F—FDG）PET（Positron Emission Tomography）-CT（computerized tomography）的标准摄取值（standafized uptake value。SUV）与预后的关系。方法选择行18F—FDGPET—CT扫描并经手术证实的NSCLC患者33例，测定原发病灶的最大SUV，结合临床病理特点，分析SUV与患者生存时间的关系。结果33例NSCLC病例PET—CT的平均最大标准摄取值（SUVmax）为10．5±5．4，SUVmax〈11与SUVmax≥11病例组的中位生存时间分别为33±0．6个月和27±1．3个月，两组的生存时间有统计学差异（P=0．013），相关分析显示SUVmax与生存时间呈显著负相关（r=0．8，P=0．008）。单因素分析显示SUV-max与年龄、性别、病理分级、TNM分期及淋巴结转移无明显相关性，SUVmax与病理类型（鳞癌和腺癌）（r=0．348，P=0．048）及临床分型（中心型和周围型）（r=0．379，P=0．029）有关。结论PET—CT的半定量指标SUV与NSCLC预后呈负相关，SUV对评价非小细胞肺癌预后具有一定的临床意义。Objective The study focused on the correlation between 2 - deoxy - 18 F - fluoro - D - glucose （ 18 F - FDG） PET （ Positron Emission Tomography） - CT （ computerized tomography ） signs with the prognosis value in non - small cell lung cancer（ NSCLC ）. Methods Thirty - three cases of non - small cell lung cancer confirmed by pathology were examined with lSF - FDG PET before operation. The maximum standaxized uptake value（ SUVmax）to the prognosis of NSCLC and the correlation between SUVmax with clinicopathological factors were analyzed respectively. Results The average SUVmax for the 33 NSCLC was 10.5 ± 5.4, SUVmax less than cut - off value of 11 exhibited a median survival of 33 ± 0.6 months while as SUVmax more than 11 possessed 27 ± 1.3 months respectively（P =0.013）. The correlation index between SUVmax and survival time was 0.8 （r = 0.8 ,P = 0. 008）. The correlation between SUVmax and histological type was significant（ r = 0. 348, P = 0. 048 ）. The correlation between SUVmax and clinical type was significant（ r =0. 379 ,P =0. 029）. There were no signifi- cant correlations between SUVmax and age, gender, differentiation, TNM stage and lymph node metastasis. Conclusion There was a negative correlation between SUVmax of 18 F - FDG - PET and prognosis for NSCLC.

关 键 词：非小细胞肺癌 正电子发射体层成像 标准摄取值 预后 

分 类 号：R730.44[医药卫生—肿瘤]