骨标志物在乳腺癌骨转移诊断与疗效观察中的作用  

The effectiveness of bone marker in the diagnosing and observing therapeutic effect of bone metastatic carcinoma

作　　者：迟伟群[1] 王福莉 隋晓凤[1] 于晓斐[1] 张超民[1] 姚玉虹[1] 

机构地区：[1]哈尔滨医科大学附属第四医院检验科,哈尔滨150001 [2]哈尔滨市第五医院

出　　处：《实用肿瘤学杂志》2012年第5期414-417,共4页Practical Oncology Journal

基　　金：基金项目：黑龙江省卫生厅项目（2010-121）

摘　　要：目的探讨I型胶原交联羧基氨基端肽（B—CrossLaps）和总骨1型前胶原氨基端延长肽（P1NP）在乳腺癌骨转移诊断与疗效观察中的临床价值。方法运用电化学发光法对B—CrossLaps、P1NP、CA15—3进行定量检测。57例乳腺癌骨转移患者按转移灶多少分为2组，分别为骨显像轻度异常组（I组）36例与骨显像明显异常组（Ⅱ组）21例。结果骨转移组β—CrossLaps、P1NP两种血清标志物较无骨转移组与对照组明显升高，差异具有统计学意义（P〈0．01），且治疗后两种指标明显低于治疗前水平（P〈0．05），随转移灶增加两种标志物水平也有升高趋势，差异具有统计学意义（P〈0．叭）。而各组间及治疗前后CA15—3无显著变化（P〉0．05）。骨标志物B—CrossLaps、P1NP对乳腺癌骨转移的诊断灵敏度分别达到71．25％与64．05％，特异性分别达到88．00％与81．99％，均高于骨显像所显示结果的50．32％和61．17％。结论血清骨标志物β—CrossLaps、P1NP水平可以反映乳腺癌骨转移患者病情变化，并可以运用于疗效监测，有较好的临床应用价值。Objective To investigate the clinical value of β -Cross Laps and P1NP in diagnosing and observing therapeutic effect of bone metastatic carcinoma. Methods Detecting β - Cross Laps, P1NP, CA15 - 3 quantitatively using the electrochemiluminescence. All the 57 patient with bone metastatic carcinoma were divided into two grouos. One（ I ）for 36 were with lighter abnormality of bone imaging. The other（ II ）were remarkableness of bone imaging. Results The concentrations of β - Cross Laps and P1NP in the group one are obviously higher than the group two and control group. The discrepancy have the statistical significance （P 〈 0.01 ）. And the concentrations of the two marker aftertherapy are also obviously lower than the concentrations before therapy （P 〈 0.05 ）, the concentrations of the two marker are also having the increasing tendency followed by the creasing of metastasis. The discrepancy have the statistical significance （ P 〈 0.01 ）. There are no significantly changes of CA15 -3 in different groups（P 〉0.05）. The sensibility of β - Cross Laps and P1NP might reached at 71.25% and 64.05%. The specificity of them might reached at 88.0% and 81.99%. Both are higher than the results of bone imaging for 50.32% and 61.17%. Conclusion The concentrations of β - Cross Laps and P1NP might reflect the alleosis of the patients of bone metastatic carcinoma. It can be used for monitoring therapeutic effect, having better clinical application worth.

关 键 词：I型胶原交联羧基氨基端肽 总骨1型前胶原氨基端延长肽 乳腺癌骨转移 

分 类 号：R737.9[医药卫生—肿瘤]