芒果甙抗肿瘤作用机制研究进展  

Research progress on mangiferin anti-tumor mechanism

作　　者：刘晓春[1] 焦伟[1] 

机构地区：[1]广西壮族自治区人民医院临检中心,南宁530021

出　　处：《中国临床新医学》2012年第10期977-981,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:桂科青0447018)

摘　　要：芒果甙是一种黄酮类化合物,具有多种生理和药理作用,近期的研究报道芒果甙具有抗肿瘤作用。芒果甙抗肿瘤作用主要包括抑制肿瘤细胞增殖生长、阻断细胞周期、诱导细胞凋亡、抑制NF-κB信号途径激活、影响E-cad介导的细胞黏附及信号转导、干预线粒体通透性转换及与化疗药物发挥联合作用等。Mangiferin is a flavonoid compound and has a variety of physiological and pharmacological effects. Recent studies have reported that mangiferin has anti-tumor effect. Mangiferin anti-tumor mechanism includes inhibi- tion of tumor cell proliferation and growth, blocking the cell cycle, induction of apoptosis, inhibition of NF-κB signa- ling pathway activation, interference in E-cadherin-mediated cell adhesion and signal transduction, intervention of mi- tochondrial permeability transition and the combined effects of chemotherapy drugs.

关 键 词：芒果甙 抗肿瘤机制 

分 类 号：R73[医药卫生—肿瘤]