三阴乳腺癌组织中p27、survivin的表达及临床意义  

Expression of p27,survivin in triple negative breast carcinoma and its clinic significance

作　　者：王琼[1] 贺玉娟[1] 刘玮[1] 付军[1] 刘蓓[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉434000

出　　处：《山东医药》2012年第35期11-13,共3页Shandong Medical Journal

基　　金：湖北省自然科学基金资助项目(2009CDB039)

摘　　要：目的探讨p27、survivin在三阴乳腺癌(TNBC)发生、发展中的作用。方法选择我院手术切除的TNBC(肿瘤组)、非特殊类型乳腺浸润性导管癌(浸润组)、良性乳腺增生症(增生组)组织标本各56份,采用免疫组化SP二部法检测各组p27、survivin的表达情况,并分析p27、survivin的表达与TNBC临床病理参数的相关性。结果肿瘤组、浸润组、增生组p27阳性表达率分别为41.1%、67.8%、91.1%,肿瘤组明显低于其余两组,浸润组明显低于增生组(P均<0.01);survivin阳性率分别为69.6%、60.7%、5.3%,肿瘤组及浸润组明显高于增生组(P均<0.01)。p27表达与TNBC的患者年龄、肿瘤直径、临床分期及淋巴结转移有关,survivin与TNBC的患者年龄、肿瘤直径有关。p27与survivin在TNBC中表达呈负相关。结论 p27、survivin异常表达可能与TNBC的发生、发展及预后密切相关。Objective To investigate the roles of p27 and survivin in the occurrence and development of triple negative breast carcinoma（TNBC） . Methods The tissue specimen from 56 cases of TNBC（tumor group） , infiltrating ductal carcinoma of breast（ infiltrating group）, benign mammary gland hyperplasia（ hyperplasia group） were collected. The protein expression of p27 and survivin was detected by immunohistochemistry, the correlation between the expression of p27, survivin and the clinicopathologic parameters of TNBC were analyzed. Results The positive expression rate of p27 in tumor group, infiltrating group and hyperplasia group was 41.1% , 67.8% and 91.1% respectively, the rate in the tumor group was significantly lower than that in the other two groups, and which in the infiltrating group was sigrfificantly lower than that in the hyperplasia group（ all P 〈 0.01 ） ; the positive expression rate of survivin was 69.6% ,60.7% and 5.3% respectively, which in the tumor group and infiltrating group was significantly higher than that in the hyperplasia group（ both P 〈0.01. The expression of p27 in TNBC was related to the patients＇s age, size of tumor, clinical stages and lymph node metastasis. The expression of survivin in TNBC was related to the patients＂ age, size of tumor. The expression of p27 was negatively correlated with the expression of survivin in TNBC. Conclusions The abnormal expression of p27 and survivin may correspond to the occurrence, development and prognosis of TNBC.

关 键 词：三阴乳腺癌 P27蛋白 SURVIVIN蛋白 

分 类 号：R737.9[医药卫生—肿瘤]