生、熟大黄对高分子右旋糖酐所致血瘀大鼠血液流变性的比较  

Comparative Study on the Influence of Stewed Rhubarb and Rhubarb on Hemorheological Parameters in Rats with Blood Stasis Induced by High Molecular Dextran

作　　者：杨涛[1] 胡昌江[1] 李文兵[1] 张彤[1] 李倩[1] 高源[1] 

机构地区：[1]成都中医药大学药学院,成都611137

出　　处：《中国实验方剂学杂志》2012年第21期248-250,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中医药行业科研专项(20110700710)

摘　　要：目的:比较生、熟大黄对高分子右旋糖酐所致血瘀模型大鼠血液流变性的影响,以阐明大黄生泻下、熟活血的炮制机制。并考察熟大黄炮制过程中加酒与否对其活血化瘀功效的影响。方法:采用ip高分子右旋糖酐制备大鼠血瘀模型,同时给予不同剂量生大黄、熟大黄及不加酒制熟大黄2.5,5.0 g.kg-1,ig,连续7 d,观察对实验动物的血液流变性的影响。结果:熟大黄高、低剂量组各指标检测值与等剂量生大黄组比较均有所减少,其中熟大黄低剂量组全血黏度与生大黄低剂量组比较具有极显著性差异(P<0.01);而无酒熟大黄高、低剂量组各指标检测值则普遍较等剂量熟大黄组高,其中全血黏度和红细胞压积均与熟大黄组有明显差异(P<0.01或P<0.05)。结论:熟大黄活血化瘀作用明显较生大黄好;加酒熟大黄活血化瘀作用明显优于无酒熟大黄。Objective： To clariiy the mechanism of purgative and promoting blood circulation on stewed rhubarb and rhubarb, by comparing the influence of them on hemorheological parameters in rats with blood stasis induced by high molecular dextran; and the influence of yellow wine in processing rhubarb on promoting blood circulation to remove blood stasis. Method： Rats with blood stasis were made by injected high molecular dextran into the abdominal cavity, in the same time, stewed rhubarb without yellow wine, stewed rhubarb and rhubarb in different doses （2.5, 5.0 g ·kg^（-1）, ig, for 7 days） were given. Then the hemorheological parameters of the rats were observed and compared. Result： The parameters of stewed rhubarb were lower than those for rhubarb at the same dose, and there was extremely significant difference in whole blood viscosity between stewed rhubarb at low dose and rhubarb at low dose （P 〈 0.01 ）. The parameters of stewed rhubarb without yellow wine were higher than those of stewed rhubarb, and there was significant difference in whole blood viscosity and hematocrit between stewed rhubarb and rhubarb （P 〈 0.01 or P 〈 0.05 ）. Conclusion： The efficiency on promoting blood circulation to remove blood stasis of stewed rhubarb is definitely better than rhubarb, and stewed rhubarb is definitely better than stewed rhubarb without yellow wine.

关 键 词：大黄 熟大黄 血液流变学 高分子右旋糖酐 黄酒 

分 类 号：R285.5[医药卫生—中药学]