人乳头瘤病毒预防性疫苗的研究进展  

Human Papilloma Virus Prophylactic Vaccine Research Progress

作　　者：阿荣其其格[1] 段仙芝[2] 尼玛 

机构地区：[1]内蒙古民族大学,2010级研究生内蒙古通辽028000 [2]北京首都医科大学附属同仁医院妇产科,北京100730 [3]赤峰市阿旗罕苏木卫生院,内蒙古赤峰025559

出　　处：《内蒙古医学杂志》2012年第7期828-831,773,共5页Inner Mongolia Medical Journal

摘　　要：20世纪80年代初德国病毒学家Harald Zur Hausen首次提出人乳头瘤病毒(Human papillomavirus)感染与宫颈癌密切相关的假设,此后国内外大量的证据使得人们对子宫颈癌和HPV的因果关联达成了共识,即HPV感染是子宫颈癌的必然病因。这一发现不但促进了基于HPVDNA检测子宫颈癌新筛查技术的发展,同时也研发成功第一种癌症预防性疫苗,即HPV预防性宫颈癌疫苗。Objective：In 1980s,Germany virologist——Harald Zur Hausen firstly raise the hypotheses that human papilloma virus（HPV） infection closely related to cervical cancer.Afterwards,lots of evidence proved the causal relationship between persistent HPV infection and cervical cancer,and made a conclusion that HPV infection is the necessary cause of cervical cancer.This discovery is marked as a milestone in cervical cancer prevention,which not only promotes the development of HPV DNA-based cervical cancer screening technology,but also guides the development of HPV prophylactic vaccine for cervical cancer.This review states the latest researches of HPV vaccine.

关 键 词：人乳头瘤病毒 宫颈癌 疫苗 

分 类 号：R737.33[医药卫生—肿瘤]