腹腔内化疗治疗在消化道肿瘤中的应用  

The Application of Postoperative Intraperitoneal Chemotherapy for Patients with Gastrointestinal Cancer

作　　者：佀军 张颖莹 

机构地区：[1]郑州市人民医院病案科,郑州450003

出　　处：《求医问药（下半月刊）》2012年第8期567-568,共2页Seek Medical and Ask The Medicine

摘　　要：目的:减少中晚期胃、结直肠恶性肿瘤术后腹腔内复发和肝脏转移率。方法:将143例患者随机分成腹腔化疗组(观察组)70例,静脉化疗组(对照组)73例。结果:观察组与对照组相比,术后腹腔内复发例数4/18,x2=9.85,p<0.005,肝转移例数1/10,x2=7.58,p<0.005,近期死亡例数2/10,x2=16.53,p<0.005,三年以上存活21/11,x2=4.59,p<0.05。结论:对该类患者术后采用5-Fu+MMC腹腔化疗在减少腹腔内复发和肝脏转移方面,近期优于静脉化疗。Objective：To reduce the postoperative recurrence and live metastasis of the gastric or colorectal carcinoma in middle or late stage patients.Methods：143 cases were randomly divided into postoperative intraperitoneal,70 cases as the observation group（OG） and iv drip,73 cases as the control group（CG）.Results：Compared to CG postoperative recurrence in OG was 4/18,x 2 =9.85,p0.005,liver metastasis 1/10,x 2 =7.58,p0.005,inhospital death 2/20,x 2 =16.53,p0.005,survival in 3 years after 21/11,x 2 =4.59,p0.05.Conclusions：Intraperitoneal 5-Fu＋MMC chemotherapy is superior to intravenous chemotherapy in reduction of postoperative recurrence and liver metastasis.

关 键 词：5氟脲嘧啶 药物化疗 肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]