色氨酸羟化酶基因多态性与单相抑郁症关系的Meta分析  

Meta - analysis on the Relationship between TPH Gene Polymorphism and Unipolar Depression

作　　者：吕少妮[1] 任淑敏[1] 王美霞[1] 张庆[1] 朱启贞[1] 田永晓[1] 

机构地区：[1]济宁医学院信息工程学院,日照276826

出　　处：《医学信息学杂志》2012年第9期40-44,共5页Journal of Medical Informatics

摘　　要：以色氨酸羟化酶(TPH)基因和单相抑郁症应关系病倒对照的国内外文献为研究对象,应用Rev-Man 5.0对数据统计分析,综合评价色氨酸羟化酶基因多态性与单相抑郁症的关系。结果表明色氨酸羟化酶基因多态性与单相抑郁症相关,其中CC基因型是单相抑郁症的易感基因,AA基因型和AC基因型与单相抑郁症无明显关联。Taking the literatures on the relationship between TPH gene polymorphism and unipolar depression both in China and a- broad as research objects, using the software of RevMan 5.0, the paper comprehensively evaluates the relations between TPH gene poly- morphism and unipolar depression. The results show that TPH gene polymorphism has significant associations with unipolar depression, CC genotype increases the risk for unipolar depression, AA and AC genotypes are not significantly associated with unipolar depression.

关 键 词：单相抑郁 色氨酸羟化酶基因 基因多态性 META分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]