代谢组学在消化道恶性肿瘤诊断中的应用进展  

Metabonomics in diagnosis of gastrointestinal cancer

作　　者：莫宇轩[1] 焦兴元[1] 石景森[2] 

机构地区：[1]中山大学附属第一医院肝胆外科,广东510080 [2]西安交通大学医学院第一附属医院普通外科

出　　处：《中华肝胆外科杂志》2012年第10期802-805,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：本课题受国家自然科学基金资助（81071984）

摘　　要：消化系统肿瘤是最为常见的恶性肿瘤，其发病率近年呈明显上升趋势。由于其早期临床表现无特异性，诊断率低，就诊时患者往往已达中晚期，失去最佳的手术机会，故预后极差。代谢组学作为一种高敏感性的研究技术，对探索消化道肿瘤的发生演变具有很大的潜力。笔者就代谢组学在消化道恶性肿瘤诊断中的应用进展进行综述。Gastrointestinal cancer is the most preva- lent cancer among malignant tumors, with a upward trend in incidence. Since there is absence of specific clinical manifes- tation as well as low diagnostic rate, patients diagnosed with cancer of digestive tract are mostly in intermediate or ad- vanced stages. Therefore, they lose the best chance of sur- gery and have a poor prognosis. Metabonomics, a kind of high sensitivity research technology, shows great potential in the exploration of occurrence and development of malignant tumor. The aim of this study was to review the progress of application in gastrointestinal cancer by metabonomics.

关 键 词：代谢组学 消化道肿瘤 诊断 

分 类 号：R735[医药卫生—肿瘤]