低强度超声促进放疗后犬下颌种植体骨结合的实验研究  

Experimental Study of the Promotion of the Low Intensity Ultrasound to the Osseointegration of Mandibule Implants after Irradiation in Canine

作　　者：陈磊[1,2] 吴高义[2] 朱国雄[2] 柳玉晓[2] 王昭领[2] 

机构地区：[1]济南市口腔医院正畸科,山东济南250001 [2]济南军区总医院口腔科,山东济南250031

出　　处：《现代生物医学进展》2012年第28期5420-5422,共3页Progress in Modern Biomedicine

基　　金：中国博士后科学基金(20100481522);中国博士后特别资助基金(20110477);山东省科技发展计划(2012GGB02002);陕西省科技发展计划(2011k12-02-02)

摘　　要：目的:探讨放射线损伤犬的下颌骨行种植术后,低强度超声是否对其周围骨组织结合具有促进作用。方法:建立下颌骨放射线损伤的动物模型,并运用低强度超声对其进行治疗,通过Micro-CT、拔出实验等观察低强度超声治疗组(实验Ⅱ组)与未用低强度超声治疗组(实验Ⅰ组),并与对照组对比,所得数据进行统计学分析。结果:成功的建立了放射线损伤的动物模型;实验Ⅱ组骨小梁的各项指标均好于实验Ⅰ组;拔出实验结果显示,实验Ⅱ组拔出力值明显大于实验Ⅰ组。统计结果显示各组之间的差异具有显著性的意义(P<0.05)。Objective： To investigate the effect of low intensity ultrasound on promoting the bone tissue repair of implanted canine mandibule after irradiation. Methods： The animal models of radioactive mandibular injury were built and treated with low intensity ultrasound. Low intensity ultrasound group （Group II ） and no low intensity ultrasound group （Group I ） were detected by Micor-CT, pull-out test. The data were statistically analyzed. Results： The animal models of radioactive mandibular injury were successfully built. All indicators of bony trabeculae in Group II were better than those in Group I . The results of pull-out test suggested that pull-out strength values in Group II were significantly larger than those in Group I . The statistical results Suggested that the differences among the groups were significant. Conclusion： Low intensity ultrasound has better recovery effect on bone tissue around implants after irradiation.

关 键 词：低强度超声 放射性骨坏死 MICRO-CT 

分 类 号：Q95-33[生物学—动物学] R78[医药卫生—口腔医学]