鞍区生殖细胞瘤的眼部表现  

The ophthalmic manifestation of germinoma in sellar region

作　　者：雷鹍[1] 瞿远珍[1] 王剑[1] 王丽娜[1] 

机构地区：[1]首都医科大学附属北京天坛医院眼科,100050

出　　处：《眼科》2012年第5期313-315,共3页Ophthalmology in China

摘　　要：目的探讨鞍区生殖细胞瘤的眼部临床表现。设计回顾性病例系列。研究对象2005年1月至2010年12月北京天坛医院诊治的鞍区生殖细胞瘤患者43例。方法回顾分析患者的视力、视野、眼底。对视力与发病年龄和病程进行相关性分析。主要指标视力，视野，眼底像。结果患者平均年龄（15．7±6．5）岁（4—31岁）。矫正视力的中位数为0．15。视力减退者52眼（74．3％），双眼盲7例（16．3％）。视力损害程度与年龄相关（r=0．384，P=0．023），即发病年龄越小视力损伤越重，而与病程无明显相关性（P=0．205）。出现视野损害者46眼（74．2％），其中以颞侧偏盲为主（46．8％）。视神经萎缩14眼（20．6％），视乳头水肿13眼（19．1％）。结论鞍区生殖细胞瘤好发于儿童和青少年，其视功能损伤程度重，致盲率高。发病年龄越小视力损伤越重。Objective To study the ophthalmic manifestation of patients with germinoma in sellar region. Design Retrospective case series. Participants 43 patients with germinoma in sellar region were collected from 2005 to 2010 in Beijing Tiantan Hospital. Method The visual acuity, fundus photographs and visual fields of patients were analyzed. The correlation analysis was performed between the vision, age and course of disease. Main Outcome Measures Visual acuty, visual field and fundus manifestation. Result The average age of patients was 15.7±6.5 （4-31） years-old. The median of corrected visual acuity was 0.15. There were 74.3% （52/70） eyes with decreased visual acuity, 74.2% （46/62） with the visual field defects, 39.7% （27/68） with fundus changes. A statistically significant correlation was found between the visual acuity and age （r=0.384, P=0.023）. There was no statistically significant correlation between the visual acuity and the course of disease. Conclusion Germinoma in sellar region could cause severe eye dysfunction and the rate of blindness was very high. The younger the patient was, the heavier the impairment of vision was.

关 键 词：鞍区生殖细胞瘤 诊断 视野 眼底 

分 类 号：R739.4[医药卫生—肿瘤]