胃(H^(+)+K^(+))-ATPase与急性胃粘膜病变的关系的研究  

Study on the Relation Between Gastric(H^++ K^+)-ATPase and Acute Gastric Mucosal Lesion

作　　者：左风蓉 吴同乐[1] 李生广[1] 陈采琴 林治焕[1] 

机构地区：[1]中国科学院生物物理所

出　　处：《生物化学杂志》1990年第2期181-185,共5页

基　　金：国家自然科学基金资助

摘　　要：本文对急性胃粘膜病变与胃粘膜(H^(+)+K^(+))-ATP_ase的关系作了初步探讨,实验结果说明以消炎痛为诱因引起大白鼠急性胃粘膜病变时胃粘膜上的胃酸分泌的质子泵(H^(+)+K^(+))-ATP_ase活力受到抑制。在离体实验中低浓度的消炎痛<2μmol,大白鼠胃粘膜(H^(+)+K^(+))-ATP_ase的活力便受到显著的抑制,在整体实验中维酶素对消炎痛引起的胃粘膜(H^(+)+K^(+))-ATP_ase的抑制具有保护作用。A preliminary investigation on the relation between the acute gastric mucosal lesion and the activity of gastric mucosal (H++K+)-ATPase is presented in this paper. The experimental results showed that when the acute gastric mucosal lesion of rats induced by indometacin appeared the activity of acid transporting (H++K+)-ATPase was inactivated.In vitro, even in low concentration of indoraetacin<2μmol the decrease of gastric mucosal (H++K+)-ATPase activety was significantly .In vivo, the drug 'crude riboflavin preparation' could exert its efffct by protecting the gastric mucosal (H++ K+)-ATPase from the inhibition caused by indometacin.

关 键 词：胃粘膜 胃粘膜病变 腺苷三磷酸酶 氢 钾 

分 类 号：R573.02[医药卫生—消化系统]