K-ras基因在结直肠癌中的表达及与病理的关系  

Detection of K-ras gene mutation in colorectal tumor and relationship with clinicopathological features

作　　者：刘启志[1] 高显华[1] 傅传刚[1] 于恩达[1] 刘连杰[1] 

机构地区：[1]第二军医大学附属长海医院肛肠外科,上海200433

出　　处：《结直肠肛门外科》2012年第4期222-224,共3页Journal of Colorectal & Anal Surgery

摘　　要：目的检测结直肠癌中K-ras基因突变情况,探讨其与结直肠癌患者病理资料的关系,为患者的靶向治疗提供基础。方法检测长海医院收治的200例结直肠癌患者K-ras基因突变情况,结合其病理资料进行统计分析。结果 K-ras基因突变者56例(28%),K-ras基因突变与肿瘤的淋巴结转移、肝转移及TNM分期关系密切(P<0.05),而与年龄、性别、肿瘤浸润深度及肿瘤分化程度等无明显相关性(P>0.05)。结论 K-ras基因突变的检测有助于筛选对抗表皮生长因子受体(epidermal growth factor receptor,EGFR)靶向治疗药物有效的结直肠癌患者。Objective To detect the expression of oncogene k-ras in colorectal cancer tissues, to find outits correlation with tumor clinicopathological features and provlcle a basxs for targetea tnerapy, lwetnous PCR method was performed to detect k-ras mutation of specimens from 200 patients with colorectal cancer in changhai hospital, and the relationship with corresponding clinical pathological data was analyzed by sta- tistical Methods. Results K-ras mutations were detected in 56 cases （28%） K-ras had a close relationship with lymph node metastasis, hepatic metastasis and TNM stage（ P 〈0.05）, but no significant relation- ship with age, sex, bowel wall invasion and tumor differentiation were found（P〉0. 05）. Conclusion K- ras can be of good use for the epidermal growth factor receptor （EGFR） targeted treatment of colorectalcancer patients.

关 键 词：结直肠癌 K-RAS 靶向治疗 

分 类 号：R735.3[医药卫生—肿瘤]