Quantum Dots for Cancer Research:Current Status,Remaining Issues,and Future Perspectives  

作　　者：Min Fang Chun-wei Peng Dai-Wen Pang Yan Li 

机构地区：[1]Department of Oncology,Zhongnan Hospital of Wuhan University,Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center [2]Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education),College of Chemistry and Molecular Sciences,and State Key Laboratory of Virology,Wuhan University

出　　处：《Clinical oncology and cancer researeh》2012年第3期151-163,共13页

基　　金：supported by the Academic Award for Excellent Ph.D.Candidates Funded by the Ministry of Education of China(No.5052011303014);the National Natural Science Foundation of China(No.81171396);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(Nos.20621502 and 20921062);the Fundamental Research Funds for the Central Universities of Ministry of Education of China(No.4103005).

摘　　要：Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the development of a novel approach for cancer detection is urgent,and real-time monitoring is crucial in revealing its underlying biological mechanisms.With the optical and chemical advantages of quantum dots(QDs),QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study.This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro,as well as the remaining issues and future perspectives.Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide. The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms. With the optical and chemical advantages of quantum dots （QDs）, QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives.

关 键 词：quantum dots molecular imaging multimodality probes 

分 类 号：R730.4[医药卫生—肿瘤]