当归挥发油β-环糊精包合物的制备工艺及定性分析  

Preparation Technology and Qualitative Analysis for β-Cyclodextrin Inclusion Compound of Angelica Oil

作　　者：朱冉[1] 郭玫[1,2] 魏舒畅[1] 余晓晖[1] 杨霞[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]甘肃省高校中(藏)药化学与质量省级重点实验室,甘肃兰州730000

出　　处：《中药材》2012年第8期1322-1326,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(30960037);兰州科技计划项目(2010-1-160)

摘　　要：目的:优选制备当归挥发油β-环糊精包合物的最佳方法。方法:采用单因素筛选及正交实验相结合,以包合率为指标,优选最佳包合工艺。结果:最佳包合方法为饱和水溶液法,包合条件为当归挥发油与β-环糊精的比例为1∶8,β-环糊精与水的比例为1∶6,搅拌时间4 h。结论:优选的包合工艺操作简便、工艺稳定、挥发油包合率较高。Objective：To optimize the preparation process of β-cyclodextrin（β-CD） inclusion compound of Angelica oil.Methods： Single factor experiment and orthogonal design were used together,oil inclusion rate was used as an index,then chose the best preparation technology.Results： The optimal method was saturated solution method.The preparation condition for inclusion was as follows： the ratio of Angelica oil to β-CD was（1∶ 8）,the ratio of β-CD to water was（1∶ 6） and the stirring time was 4 h.Conclusion： The preparation procedure of inclusion volatile oil is simple,stable,reliable and high inclusion rate.

关 键 词：当归挥发油 Β-环糊精 包合 

分 类 号：R286.1[医药卫生—中药学]