4-甲氧基-3-[3-(吗啉-4-基)丙氧基]苯甲腈的合成研究  

Synthesis of 4-Methoxy-3-(3-morpholinopropoxy)benzonitrile

作　　者：杨诗婧[1] 贾云宏[1] 蔡东[1] 郝月[1] 

机构地区：[1]辽宁医学院药学院,锦州121001

出　　处：《化学通报》2012年第10期945-947,共3页Chemistry

摘　　要：以3-羟基-4-甲氧基苯甲醛为原料,在甲酸、甲酸钠、盐酸羟胺作用下,将醛基转化为氰基,在含有碳酸钾的DMF中,所得化合物与N-(3-氯丙基)吗啉反应得目标化合物,总收率为87.5%。产物结构由1HNMR表征。本方法具有操作简单、易于纯化、收率高等特点,为工业化生产提供实验基础。The titled compound was synthesized from 3-hydroxy-4-methoxybenzaldehyde.The formyl group was transformed to cyano group via the reaction with hydroxylammonium sulfate in the presence of sodium formate in formic acid,then the corresponding intermediate reacted with N-（3-chloropropyl）morpholine,the total yield was up to 87.5%.The products were characterized with 1H NMR.The synthetic route exhibits the advantages in purification and total yield of the final product compared with the previous ones.

关 键 词：4-甲氧基-3-(3-吗啉-4-基丙氧基)苯甲腈 合成 工业化 

分 类 号：TQ246.7[化学工程—有机化工]