鹿花盘蛋白对乳腺增生模型小鼠作用研究  

Immunoregulatory Effect of Deer Antler Base Proteins on Mammary Gland Hyperplasia in Mice

作　　者：王莘[1] 姚艳飞[1] 

机构地区：[1]吉林农业大学生命科学学院,吉林长春130118

出　　处：《食品科学》2012年第19期295-297,共3页Food Science

基　　金：长春市科技局重大攻关项目(2008214)

摘　　要：目的:观察鹿花盘蛋白对乳腺增生小鼠雌激素水平及免疫功能方面的影响。方法:采用苯甲酸雌二醇联合黄体酮制备动物模型,饲喂鹿花盘蛋白,检测每组小鼠血清雌二醇含量、子宫系数,以及免疫器官系数。结果:与模型组比较,鹿花盘蛋白组能够显著降低乳腺增生小鼠血清雌二醇含量及子宫系数(P<0.05),并能明显增加胸腺系数及脾脏系数(P<0.05)。结论:鹿花盘蛋白能够调节乳腺增生小鼠雌激素分泌,增强机体免疫水平。Objective： To investigate the effect of deer antler base proteins on estrogen level and immune function in mice with mammary gland hyperplasia. Methods： Mouse models of mammary gland hyperplasia were established by combined injection of estradiol benzoate and progesterone. After administration with deer antler base proteins for 25 consecutive days, the mouse models were tested for serum estradiol level, uterus coefficient and immune organ coefficients. Results： In comparison with the model group, the treatment group showed a significant reduction in serum estradiol level and uterus coefficient of mice with mammary gland hyperplasia （P〈0.05） and a significant increase in thymus coefficient and spleen coefficient （P〈0.05）. Conclusion： Deer antler base proteins regulate the secretion of estrogens and enhance immune function in mice.

关 键 词：鹿花盘 蛋白 雌二醇 免疫功能 

分 类 号：TS285.5[轻工技术与工程—食品科学与工程]