肿瘤标志物血清P53抗体在结直肠癌根治术后随访中的价值  

Value of serum P53 antibody as a tumor marker surveillance of colorectal cancer within follow-up after curative resection

作　　者：寿成超[1] 黄昊[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所、恶性肿瘤发生机制及转化研究教育部重点实验室

出　　处：《中华胃肠外科杂志》2012年第10期1020-1022,共3页Chinese Journal of Gastrointestinal Surgery

摘　　要：因P53基因突变而产生的异常P53蛋白，可导致机体产生抗P53抗体。大量研究表明．血清P53抗体水平与许多肿瘤患者预后、结直肠癌淋巴结侵袭与转移以及结直肠癌根治术后的复发等均具有一定的相关性．有可能作为肿瘤标志物用于对患者预后及结直肠癌根治术后早期复发和转移的判断。血清P53抗体水平的检测有潜在的临床应用价值．但真正进入临床应用．仍有大量的工作要做。P53 gene mutations and the abnormal P53 protein can introduce the production to P53 antibody. A large number of studies showed that serum levels of P53 antibody had the correlation with the prognosis of patients with different cancers, the lymph node invasion and metastasis of colorectal cancer, and its recurrence after the curative resection. And it is possible for its application in predicting the early recurrence and metastasis in colorectal cancer after the curative resection. However, there are still a lot of work needed to be done before its use in the clinical settings.

关 键 词：结直肠肿瘤 血清P53抗体 根治性手 术预后 

分 类 号：R735.3[医药卫生—肿瘤]