门急诊和配置中心环境下输液配置微生物污染比较  

Comparing microbial contamination situation of infusion configuration in outpatient and emergency department and PIVAS

作　　者：罗建华[1] 徐萍[1] 王诚[1] 阮大山 王伟 张勇 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003 [2]中国大冢制药有限公司,天津300040

出　　处：《中国新药与临床杂志》2012年第10期627-629,共3页Chinese Journal of New Drugs and Clinical Remedies

基　　金：苏州市科技发展计划项目(编号SYSD2011140)

摘　　要：目的研究在门急诊和配置中心环境下输液配置过程中及完成后到临床使用期间的微生物污染情况。方法实验分门急诊组和配置中心组,每组400份供试品(10%葡萄糖注射液+10%氯化钠注射液+复方注射用水溶性维生素),分别在门急诊和配置中心环境中按照无菌操作法配置静脉输液,操作时分别穿刺1、3、6、9次,每个穿刺次数各100份供试品,配置完成后放置0、2、4、6、8 h后进行无菌检查。数据统计分析采用SPSS18.0软件。结果门急诊环境下进行配置操作的阳性检出率为14.5%,配置中心则未检出;统计分析显示,当穿刺超过1次或任何放置时间下,2组间微生物污染有显著差异;穿刺6次以上,放置2、6、8 h时,2组间微生物污染有显著差异。结论门急诊环境下配置输液和放置输液成品均较配置中心环境下存在更高的微生物污染风险,门急诊输液配置和放置最好在净化环境中完成。AIM To study microbial contamination situation of infusion in outpatient and emergency department and Pharmacy Intravenous Admixture Services （PIVAS） during and after the infusion preparation process. METHODS The experiment was divided into outpatient and emergency department group and PIVAS group. Each group has 400 test samples （10% glucose injection ＋ 10% sodium chloride injection ＋ compound water soluble vitamin for injection）. The intravenous infusion were configured according to aseptic technique in outpatient and emergency department and PIVAS respectively. The intravenous infusion were punched 1, 3, 6 and 9 times respectively at operation, each punch group has 100 test samples. The prepared infusion were placed 0, 2, 4, 6 and 8 hour respectively. The data analysis was used SPSS18.0. RESULTS Bacterial contamination positive rate of outpatients and emergency department was 14.5%, while PIVAS was not detected. Statistical analysis showed that, when the puncture more than 1 time or placing any time, two groups had significant difference in microbial pollution; when the puncture above 6 times, placing 2, 6, 8 hours, two groups had significant difference in microbial contamination. CONCLUSION Preparation and storage infusion products in outpatient and emergency department has higher microbial contamination risk than PIVAS. It is suggest that the infusion should be finished in purified environment.

关 键 词：输注 静脉内 微生物学 灭菌 配置中心 

分 类 号：R943[医药卫生—药剂学]