诊断多发性硬化的两种McDonald标准的比较研究  

Comparative Study on Two McDonald Criteria for Diagnosis of Multiple Sclerosis

作　　者：刘广志[1] 何洋[1] 杨亭亭[1] 高旭光[1] 许贤豪[2] 

机构地区：[1]北京大学人民医院神经内科,北京市100044 [2]卫生部北京医院神经内科

出　　处：《中国全科医学》2012年第25期2882-2883,共2页Chinese General Practice

基　　金：国家自然科学基金资助项目(81171123)

摘　　要：目的对诊断多发性硬化(MS)的2005年修订版和2010年简化版McDonald标准进行比较,了解两种标准诊断的敏感性。方法选取78例临床表现提示为MS的患者,采用2005年修订版和2010年简化版McDonald标准进行诊断,采用Fisher精确概率法进行比较。结果符合2005年修订版McDonald标准的MS确诊者51例(65.4%),可能MS者27例(34.6%);符合2010年简化版McDonald标准的MS确诊者57例(73.1%),可能MS者21例(26.9%)。两种标准的诊断阳性率间差异无统计学意义(P>0.05)。结论 2010年简化版McDonald标准的MS诊断敏感性略高于2005年修订版,主要系时间多病灶MRI标准的简化所致,提示简化后的McDonald标准具有良好的实用性。Objective To compare the revised diagnostic criteria of multiple sclerosis （MS） proposed by McDonald et al in 2005 and 2011 so as to know the sensibility of the two diagnosis criteria. Methods Totally 78 patients with clinical features suggestive of MS were chosen and they were then diagnosed by the two diagnostic criteria. Then the Fisher＇s exact test was used for comparison. Results According to 2005 - revised McDonald criteria, 51 patients （65.4%） were diagnosed as having MS and 27 （34. 6% ） as possibly having MS; while according to 2010 -rivesed McDonald criteria the numbers were respectively 57 （73.1%） and21 （26.9%）, with no significant difference （P 〉0.05）. Conclusion The 2010 -revised McDonald criteria has slightly higher sensitivity compared with the 2005 - revised, which is mainly due to the simplification of MRI criteria demon- strating dissemination of lesions in time, suggesting a potential clinical feasibility of the 2010 revision.

关 键 词：多发性硬化 McDonald标准 诊断 

分 类 号：R744.51[医药卫生—神经病学与精神病学]