脑膜血管瘤病伴少突胶质细胞瘤临床病理观察  

Meningioangiomatosis-associated oligodendroglioma:a clinicopathological analysis

作　　者：洪柳[1] 孟宇宏[1] 虞积耀[1] 路平[1] 宁浩勇[1] 刘新尧[1] 段敏刚[1] 

机构地区：[1]海军总医院病理科,北京100048

出　　处：《诊断病理学杂志》2012年第5期343-347,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨脑膜血管瘤病(MA)的临床、影像学和组织学特点及鉴别诊断。方法报告脑膜血管瘤病伴少突胶质细胞瘤1例并复习文献。结果散发性MA发病较年轻,临床表现以癫多见;影像学差异较大,无特异性。本例镜下大部分呈MA的组织学特点,即软脑膜上皮细胞、脑膜血管和血管周梭形纤维母细胞结节状或旋涡状增生,形成边界清楚的皮质内斑块,另见少许少突胶质细胞瘤成分(WHOⅡ级)。免疫组化:梭形细胞vimentin和CD34(+),EMA和CKAE1/AE3(-)。结论 MA是罕见的良性病变,可伴发少突胶质细胞瘤、脑膜瘤等;单纯切除是首选治疗,预后良好。Objective To investigate the clinical characteristics,radiological features,histopathologic features and differential diagnosis of meningioangiomatosis.Methods One case of meningioangiomatosis accompanied with oligodendroglioma was reported and related literatures were reviewed.Results The patients of spordic meningioangiomatosis were more younger and the clinical presentation was more commonly as epilepsy.The imaging feature was various and non-specific.Histopathologically,the main features was meningioangiomatosis（leptomeningeal meningothelial and meningovascular proliferation;the perivascular spindle fibroblast cell proliferation,nodular or swirling;the formation of the cortex plaque with a clear boundary）.Otherwise,a little part of oligodendrocyte was also included.The spindle cells in meningioangiomatosis were positive for vimentin and CD34,but negitve for EMA and CKAE1/AE3.Conclusions MA is a rare benign lesion.Sometimes it may be associated with oligodendroglioma,meningioma and others.Surgical excision is the preferred treatment and the prognosis is good.

关 键 词：脑膜血管瘤病 少突胶质细胞瘤 影像学 组织病理学 鉴别诊断 

分 类 号：R739.41[医药卫生—肿瘤]