ETS-1、p53、VEGF、EGFR、HER-2、COX-2在胰腺癌中的表达  

Expressions of ETS-1,p53,VEGF,EGFR,HER-2 and COX-2 in pancreatic cancer

作　　者：王彩莲[1] 王文闻[1] 

机构地区：[1]东南大学附属中大医院肿瘤科,江苏省210009

出　　处：《江苏医药》2012年第20期2393-2396,F0003,共5页Jiangsu Medical Journal

基　　金：江苏省自然科学基金(SBK201123123)

摘　　要：目的研究胰腺癌组织中E26转录因子1(ETS-1)、p53、血管内皮生长因子(VEGF)、表皮生长因子受体(EGFR)、人类表皮生长因子受体2(HER-2)和环氧化酶2(COX-2)的蛋白表达及其与胰腺癌临床病理学特征的相关性。方法收集40例胰腺癌患者组织标本,免疫组化SP法检测肿瘤组织中各蛋白表达水平。分析ETS-1蛋白表达与患者临床病理学特征的相关性和ETS-1蛋白表达与p53、VEGF、EGFR、HER-2、COX-2蛋白表达之间的相关性。结果ETS-1、p53、VEGF、EGFR、HER-2、COX-2蛋白在胰腺癌组织中阳性表达率分别为65.0%、60.0%、37.5%、62.5%、37.5%、55.0%。ETS-1蛋白表达水平越高,脉管内癌栓发生率越高,肿瘤分期越晚(P<0.05)。胰腺癌中ETS-1蛋白呈高表达时,p53、COX-2蛋白也呈高表达状态(P<0.05)。结论胰腺癌组织中存在ETS-1、p53、VEGF、EGFR、HER-2、COX-2蛋白表达。ETS-1高表达的胰腺癌患者肿瘤分期晚,预后差。ETS-1蛋白高表达促胰腺癌发生发展机制可能与p53、COX-2蛋白高表达相关。Objective To analyze the expressions of E26 transcription factor-1 （ETS-1）, p53, vascular endothelial growth factor（VEGF）, epithelial growth factor receptor（EGFR）, human epithelial factor receptor-2 （HER-2） and cyclooxegenase-2 （COX-2） and their correlation with clinicopathological characteristics of the patients with pancreatic cancer. Methods The expressions of ETS-1, p53, VEGF, EGFR, HER-2 and COX-2 proteins were detected with immunohistoehemistry SP stain. Chi-square test was applied to analyze the correlations of the expressions of ETS-1 with clinicopathological characteristics and those proteins. Results The expression rates of ETS-1, p53, VEGF, EGFR, HER-2 and COX-2 proteins in pancreatic cancer were 65.00%, 60. 00%, 37. 50%, 62. 50%, 37. 50% and 55.00%, respectively. The higher expression level of ETS-1, the higher probability for vascular invasion and the later stage of TNM（P〈0. 05）. The expression level of ETS- 1 protein was significantly correlated with the expression levels of p53 and COX-2 （P〈0. 05）. Conclusion The ETS-1, p53, VEGF, EGFR, HER-2 and COX-2 proteins are expressed in the human pancreatic cancer tissues, which are higher in the patients with later stage of TNM and poorer prognosis. The mechanism for ETS-1 high expression to promote the occurrence and development of pancreatic cancer might be related to the high expressions of p53 and COX-2.

关 键 词：胰腺癌 E26转录因子1 

分 类 号：R737[医药卫生—肿瘤]