进展性脑卒中与血脂、颈内动脉斑块和狭窄及降脂治疗的关系  

Relationship between progressive stroke and blood lipids,internal carotid artery stenosis and plaque,lipid lowering therapy

作　　者：杨宁[1] 梁兵[2] 蒲蜀湘[2] 聂万锋[1] 

机构地区：[1]广州医学院第五附属医院神经内科,510700 [2]广州医学院第二附属医院神经内科

出　　处：《临床神经病学杂志》2012年第5期381-382,共2页Journal of Clinical Neurology

基　　金：广东省自然科学基金(10151018201000022);广东省科技计划项目(2009B030801363)

摘　　要：目的探讨进展性脑卒中(PS)与血脂、颈内动脉斑块和狭窄及降脂治疗的关系。方法对45例PS及45例非PS(NPS)患者进行血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平检测,以及颈内动脉彩色超声多普勒检查。采用多因素Logistic回归分析其对PS的影响。结果 PS组患者LDL-C水平明显高于NPS组(P<0.01)。PS组有颈内动脉斑块和狭窄的比率(75.6%)显著高于NPS组(42.2%)(P<0.01);而降血脂治疗的比率(51.1%)显著低于NPS组(80.0%)(P<0.05)。Logistic回归分析显示,LDL-C(OR=5.035)、颈内动脉斑块和狭窄(OR=3.224)为PS的危险因素,降血脂治疗(OR=0.175)为PS的保护因素(P<0.05～0.01)。结论血LDL-C水平高及颈内动脉斑块和狭窄为PS发病的危险因素,降血脂治疗对PS具有预防作用。Objective To explore the relationship between the progressive stroke （PS） and blood lipids, internal carotid artery stenosis and plaque, lipid lowering therapy. Methods The total cholesterol （TC）, triglycerides （ TG）, low-density lipoprotein chol esterol （ LDL-C ） and high-density lipoprotein cholesterol （ HDL-C ） of 45 patients with PS and 45 patients with non-progression stroke （NPS） were examined. Internal carotid artery was examined by color ultrasound Doppler. Their influences on PS were analyzed by Logistic regression analysis. Results LDL-C levels in PS group was significantly higher than that in NPS group （ P 〈 0. 01 ）. The rate of internal carotid artery stenosis in the PS group （75.6%） was significantly higher than that in the NPS group（42.2% ） （P 〈0.01 ）. The rate of lipid-lowering therapy in the PS group （51. 1% ） was significantly lower than that in the NPS group （ 80.0% ） （ P 〈 0. 05 ）. The logistic regression analysis showed that LDL-C （ OR = 5. 035 ） , internal carotid artery plaque and stenosis（ OR = 3. 224） were risk factors of the PS, and the lipid-lowering therapy（ OR = 0. 175 ） was the protective factor（P 〈 0. 05 -0.01 ）. Conclusions The high LDL-C, internal carotid artery plaque and stenosis are important risk factors of PS. The lipid-lowering therapy has preventing effect on PS.

关 键 词：进展性脑卒中 血脂 颈动脉狭窄 斑块 

分 类 号：R743.3[医药卫生—神经病学与精神病学]