精神分裂症主要易感基因的研究进展  

Research progress in studies on main susceptibility genes of schizophrenia

作　　者：李大伟[1] 顾鸣敏[1] 

机构地区：[1]上海交通大学医学院医学遗传学教研室,200025

出　　处：《国际遗传学杂志》2012年第5期283-289,共7页International Journal of Genetics

基　　金：基金项目：国家自然科学基金资助项目（31071107）

摘　　要：精神分裂症（schizophrenia，SCZ）是一种常见的、复杂的精神疾病，至今原因不明。一般认为该病是环境因素和遗传因素共同作用的结果。近年来的研究证实，遗传因素在SCZ发病过程中起着重要的作用。采用全基因组扫描与连锁分析、全基因组关联研究与连锁不平衡分析，已发现了一系列SCZ的易感基因，其中包括DTNBPl、COMT、DISCl和NRGl等。此文在简要介绍该病研究策略的同时．综述上述几种SCZ易感基因的研容讲展。Schizophrenia is a common and complex mental disorder with unknown etiology, and it has been widely considered to be influenced by environment and heredity. In recent years, many relevant researches have proven that genetic factors play an important role in the pathogenesis of schizophrenia. Taking advantage of whole genome scanning and linkage analysis, genome-wide associate study and linkage disequilibrium analysis, a series of susceptibility genes have been found, such as DTNBP1, COMT, DISC1 , NRG1. This paper briefly reviews above-mentioned susceptibility genes, and introduces the latest relevant research achievements.

关 键 词：精神分裂症 易感基因 精神疾病 全基因组关联研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]