DNA和RNAG．四链体及其小分子配体研究进展  

DNA,RNA G-quadruplex and their small molecular ligands:research advances

作　　者：郭佳[1,2] 李凤然[1,2] 刘洋[1,2] 华会明[1,3] 程卯生[1,2] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,沈阳110016 [2]沈阳药科大学制药工程学院,沈阳110016 [3]沈阳药科大学中药学院,沈阳110016

出　　处：《国际药学研究杂志》2012年第5期358-367,共10页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81172958)

摘　　要：近年研究表明,G-四链体在原癌基因启动子、端粒DNA和信使RNA非编码区均过度表达,寻找能够稳定或诱导这些G-四链体的配体分子,继而抑制基因的转录及相关蛋白的翻译过程,将会发展成为一种新型的抗癌策略。本文对G-四链体结构数据库及以此为靶点的抗癌机制和小分子配体研究进展进行综述。In recent years, Gquadruplexes overexpression has been found in different biologically significant regions, such as oncogenepromoter regions, human telomeres DNA and mRNA 5＇untranslated region （UTR）. Therefore, a novel anticancer strategy may be developed by searching some ligands to stabilize or to induce the Gquadruplexs so as to inhibit cancer gene transcription and translation process. The current structural database of folding topologies, the anticancer mechanism targeting different types of G quadruplex, and the progresses on the corresponding small molecular ligands as potent antitumor agents are summarized in this re

关 键 词：G.四链体 癌基因启动子 5'-非编码区 端粒重复RNA序列 抗肿瘤药 

分 类 号：R914[医药卫生—药物化学]