金丝桃素在肿瘤治疗和诊断中的应用  

Application of hypericin in cancer therapy and diagnosis

作　　者：张传力[1] 范健[1] 

机构地区：[1]扬州大学医学院,扬州225001

出　　处：《国际药学研究杂志》2012年第5期402-404,408,共4页Journal of International Pharmaceutical Research

摘　　要：金丝桃素是从金丝桃属植物中分离得到的一种天然光敏剂。金丝桃素经光激活产生过氧化物可以诱导癌细胞凋亡并抑制其生长,同时其对肿瘤组织具有特异的亲和力(可以优先积聚在肿瘤组织),这种生理活性在光学诊断中已得到广泛应用。本文对金丝桃素基于光学性质的抗肿瘤作用及在光动力学诊断中的应用进行了概述,为充分利用金丝桃素资源,进行金丝桃素衍生物的研究和开发提供依据。Hypericin, used as a medicinal herb since ancient times, is a natural photosensitizer derived from the plant Hyperi- cum perforantum. Hypericin would produce peroxides to induce apoptosis and inhibit the growth of oncocytes. Meanwhile, hypericin has a specific affinity with tumor pathology organization（ underlying accumulation in pathology organization） which has been widely used in optical diagnosis. The present review gives a comprehensive summary of the anticancer effect based on photodynamic therapy, and photodynamic diagnosis of hypericin optical properties, with the purpose of making full use of the hypericin natural resources, and pro- viding a basis for research and development of hypericin derivatives.

关 键 词：金丝桃素 光敏剂 光动力学疗法 抗肿瘤 光动力学诊断 

分 类 号：R730.5[医药卫生—肿瘤]