VEGF和MMP-9在肝癌病理诊断中的应用价值  

Application Value of VEGF and MMP-9 in Pathological Diagnosis of Liver Cancer

作　　者：郭晓东[1] 张苧月 赵景民[1] 熊璐[1] 周光德[1] 赵雨来[1] 

机构地区：[1]解放军第302医院,北京100039 [2]总后丰台综合仓库(62370部队)药材供应站,北京100039

出　　处：《现代生物医学进展》2012年第25期4845-4847,共3页Progress in Modern Biomedicine

基　　金：国家"十二五"科技重大专项课题(2012ZX10002-003)

摘　　要：目的:探讨血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在原发性肝癌(PHC)组织中的表达及病理诊断价值。方法:采用免疫组化法,检测80例PHC标本和30例正常组织中VEGF和MMP-9的表达。结果:PHC组VEGF和MMP-9阳性表达率分别为68.8%、62.5%,均显著高于对照组(23.3%、26.7%),相比较有显著性差异(P<0.05)。肿瘤直径≥5 cm、无包膜和低分化肿瘤组织中VEGF和MMP-9阳性表达均显著高于肿瘤直径<5 cm、包膜完整和高中分化肿瘤组,相比较有显著性差异(P<0.05);而VEGF和MMP-9阳性表达在不同性别和年龄构成之间、有癌栓组和无癌栓组之间、AFP阳性组和阴性组之间差异无统计学意义(P>0.05)。结论:VEGF和MMP-9在PHC组织中呈高表达,VEGF和MMP-9可以作为PHC的预后指标。Objective： To study the expression of VEGF and MMP-9 in tissue of primary hepatocareinoma（PHC） and application value in pathological diagnosis of PHC.Methods： The VEGF and MMP-9 expression from 80 cases of PHC tissues and 30 cases of nor-mal tissue were detected by immunohistochemical method.Results： The VEGF and MMP-9 positive rate of the PHC group was 68.8% and 62.5%,and the normal tissue group was 23.3% and 26.7%,respectively,having significant differences（P0.05）.The VEGF positive rate in tissue of tumor diameter ≥ 5 cm,no capsule and poorly differentiated tumor were significantly higher than the diameter 5 cm,encapsulated,high-moderately differentiated tumor（P 0.05）.The VEGF positive rate was no significantly different among the different gender and age,with or without thrombosis,AFP-positive group and negative group（P0.05）.Conclusion： The VEGF and MMP-9 hav high expression in PHC tissues.The VEGF and MMP-9 can be used as prognostic indicators of PHC.

关 键 词：血管内皮生长因子 基质金属蛋白酶-9 原发性肝癌组织 免疫组化 

分 类 号：R735.7[医药卫生—肿瘤]