视神经脊髓炎的研究进展  

Neuromyelitis Optica (review)

作　　者：谢圣瑞 

机构地区：[1]瑞金市人民医院神经内科,江西瑞金市342500

出　　处：《中国康复理论与实践》2012年第10期939-940,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：视神经脊髓炎(NMO)是一种累及视神经和脊髓的脱髓鞘免疫性疾病。NMO区别于多发性硬化(MS)亚型的特异性标志物是NMO-IgG,即抗水通道蛋白4(AQP4)抗体。AQP4主要分布于中枢神经系统,参与胶质细胞与脑脊液、血液之间水的调节。NMO-IgG与AQP4结合激发免疫反应导致病灶中AQP4蛋白显著减少甚至丧失是NMO病理机制。Neuromyelitis optica（NMO） is a rare demyelinating disease,affecting selectively optic nerve and spinal cord.NMO-IgG,an auto-antibody against aquaporin-4（AQP4）,identifies NMO as a disease entity separating from a severe variant of multiple sclerosis（MS）.AQP4 is particularly abundant on the central nervous system,and is involves in regulation of water among of glial cells,and the blood and cerebrospinal fluid.NMO-IgG can target the AQP4 and initiate immune response leading to AQP4 protein loss in lesions,which is the key pathological mechanism of NMO.

关 键 词：视神经脊髓炎 水通道蛋白4 视神经骨髓炎抗体 综述 

分 类 号：R744.5[医药卫生—神经病学与精神病学]