热疗联合同步放化疗治疗中晚期食管癌的临床研究  

Treatment of advanced esophageal cancer with hyperthermia combined with concurrent chemoradiotherapy

作　　者：曾守群[1] 陈远航[1] 何平[1] 杨雪梅[1] 黎斌[1] 曾贵林[1] 

机构地区：[1]四川省成都市第五人民医院肿瘤科,611130

出　　处：《重庆医学》2012年第30期3175-3176,共2页Chongqing medicine

摘　　要：目的观察热疗联合同步放化疗治疗中晚期食管癌的近期疗效、不良反应。方法 66例不能手术或不同意手术的中晚期食管癌患者,随机分成两组,治疗组应用深部热疗联合同步放化疗,对照组应用同步放化疗,比较两组近期疗效和不良反应。结果治疗组近期疗效高于对照组,差异有统计学意义(P<0.05);治疗组在骨髓抑制、胃肠道反应及放射性食管炎发生率方面均低于对照组,差异有统计学意义(P<0.05)。结论热疗联合同步放化疗治疗中晚期食管癌疗效优于同步放化疗,并且降低了放化疗的不良反应,值得进一步探讨。Objective To observe the efficacy of hyperthermia combined with concurrent chemoradiotherapy for advanced esophageal cancer.Methods 66 patients with advanced esophageal cancer either inoperable or who refused operation were randomized into two groups.Treatment group received hyperthermia combined with concurrent chemoradiotherapy.The control group was treated only with concurrent chemoradiotherapy in the same way.Immediate curative and side effects were evaluated.Results The overall response rate of treatment group was higher than that of the control group,the differences were statistically significant（P〈0.05）.The incidence rate of bone marrow suppression,gastrointestinal reactions and radioactive esophagitis in treatment group was lower than that in the control group,the differences were statistically significant（P〈0.05）.Conclusion The clinical effects of hyperthermia combined with concurrent chemoradiotherapy for advanced esophageal cancer is better than that of concurrent chemoradiotherapy,and hyperthermia can reduce adverse reactions of chemoradiotherapy.So it is well further study.

关 键 词：食管肿瘤 高温 诱发 放射治疗 药物治疗 

分 类 号：R735.1[医药卫生—肿瘤]