抗抑郁焦虑药物治疗慢性功能性便秘临床观察  

Clinical observation of anti-anxiety and anti-depressant drugs to treat chronic functional constipation

作　　者：闫志辉[1] 崔立红[1] 王晓辉[1] 李超[1] 贺星[1] 

机构地区：[1]第二军医大学海军临床医学院消化内科,北京100048

出　　处：《临床荟萃》2012年第22期1960-1963,共4页Clinical Focus

摘　　要：目的探讨抗抑郁焦虑药在慢性功能性便秘的治疗效果及临床意义。方法对我院收治的2009年2月至2012年3月慢性功能性便秘患者90例随机平均分为A、B、C 3组,A组给予聚乙二醇4000联合小剂量帕罗西汀,B组单用聚乙二醇4000,C组给予小剂量帕罗西丁。治疗1个月后对所有患者抑郁自评量表(SDS)、焦虑自评量表(SAS)及临床症状评分进行统计学分析。结果治疗1个月后A组临床治疗有效率100%高于B、C组86.7%、80.0%,且A组平均症状评分(2.49±1.62)分显著低于B、C组(5.48±2.52)分、(5.61±2.46)分(P<0.05)。各组间患者SAS、SDS评分与症状评分呈正相关(rSDS=0.679、0.841、0.878,rSAS=0.749、0.851、0.818,均P<0.05)。结论慢性功能性便秘患者抑郁、焦虑自评量表结果与临床症状评分存在密切相关性,抗抑郁药物能有效缓解临床症状,降低复发率,具有重要临床治疗意义。Objective To analyze and explore the effects and clinical significance of anti-anxiety and anti-depressant drugs in the treatment of chronic functional constipation.Methods From February 2009 to March 2012,90 cases of patients with chronic functional constipation were randomly divided into A,B,C groups,A group was given polyethylene glycol 4000 with low-dose paroxetine,group B singly with polyethylene glycol 4000,group C singly with the same low-dose of paroxetine.After treatment for a month,Self-rating Depression Scale（SDS）,Self-Rating Anxiety Scale（SAS） and clinical symptom scores of all patients were statistically analyzed.Results After a month of treatment,clinical effective rate of A group was 100%,which was significantly higher than that of B,C group,86.7%,80.0%,the average symptom score of A group 2.49±1.62 was significantly lower than that of B and C 5.48±2.52,5.61±2.46（P〈0.05）.SAS and SDS of all groups were positively correlated with symptom score（rSDS=0.679,0.841,0.878,rSAS=0.749,0.851,0.818,all P〈0.05）.Conclusion SAS and SDS correlate closely with clinical symptom score in chronic functional constipation patients,anti-anxiety and anti-depressant drugs could effectively relieve symptoms,reduce the relapse rate,with important therapeutic implications.

关 键 词：便秘 聚乙烯二醇类 帕罗西汀 

分 类 号：R574.4[医药卫生—消化系统]