雷公藤提取物对神经退行性疾病的作用机制研究进展  

The Research Progress on Mechanism of Tripterygium Wilfordii Extract for Neurodegenerative Diseases

作　　者：赵薇[1] 曾常茜[1] 

机构地区：[1]大连大学医学院,辽宁大连116622

出　　处：《中国执业药师》2012年第11期48-51,共4页China Licensed Pharmacist

基　　金：大连市科学技术基金计划项目(2008J21JH005)

摘　　要：雷公藤提取物在阿尔茨海默病、帕金森病、实验性自身免疫性脑脊髓炎、脑缺血等神经退行性疾病中,通过促进B细胞淋巴瘤因子-2蛋白表达抑制神经元凋亡;通过抑制肿瘤坏死因子α、白细胞介素-1β的转录减轻神经炎症反应;通过增加多巴胺的分泌水平提高多巴胺能神经元存活率。雷公藤提取物具有显著的抗神经炎症及抗神经元凋亡作用,有望成为延缓神经退行性疾病病程的重要手段。In neurodegenerative diseases such as Alzheimer＇s disease, Parkinson disease, experimental autoim- mune encephalomyelitis and cerebral ischemia, tripterygium wilfordii extract can inhibit neuronal apoptosis through in- creasing the expression of bcl-2, alleviate nerve inflammation through inhibition of transcription of inflammatory cy- tokines such as TNFct and IL-113, as well as improve the survival rate of dopaminergic neurons through increasing the secretion of dopamine. Therefore the extract of tripterygium wilfordii has obvious effects of anti-inflammation of nerves and anti-neuron apoptosis, and it is expected to be used as one of the important means to relieve neurodegener- ative diseases.

关 键 词：雷公藤提取物 神经退行性疾病 神经元 

分 类 号：R741[医药卫生—神经病学与精神病学]