ER、PR、HER-2、Ki67、Nm23、P53在多中心性乳腺癌中的表达及临床意义  

Expressions and significances of ER,PR,HER-2,Ki67,Nm23, P53 in multicentric breast cancer

作　　者：杨丽丽[1] 梁莉萍[1] 赵峰[1] 

机构地区：[1]新疆医科大学附属肿瘤医院病理科,乌鲁木齐830011

出　　处：《重庆医科大学学报》2012年第11期964-967,共4页Journal of Chongqing Medical University

摘　　要：目的:探讨多中心性乳腺癌雌激素受体(Estrogen receptor,ER)、孕激素受体(Progesterone recetor,PR)、原癌基因人类表皮生长因子受体-2(Human epidermal growth factor receptor-2,HER-2)、增殖细胞核抗原(Ki67 antigen,Ki67)、Nm23基因(Nm23 gene,Nm23)、P53基因(P53 gene,P53)的表达及意义。方法:回顾性分析新疆医科大学附属肿瘤医院2005-2010年期间45例多中心性乳腺癌的临床病理资料,同时选取60例单侧单发性乳腺癌作为对照。结果:①HER-2、Ki67在多中心性乳腺癌中的表达较单侧单发乳腺癌高,差别具有统计学意义(P<0.05);Nm23在多中心性乳腺癌中的表达较单侧单发乳腺癌低,差异具有统计学意义(P<0.05);ER、PR、P53在多中心性乳腺癌中的表达较单侧单发乳腺癌低,但差异不具有统计学意义(P>0.05)。②多中心性乳腺癌中,ER、PR、HER-2、Ki67、Nm23、P53在特殊类型乳腺癌中的表达与非特殊类型乳腺癌中的表达差异没有统计学意义(P>0.05)。③PR在多中心性乳腺癌中组织学分级高的较分级低的表达低,差异具有统计学意义(P<0.05),组织学分级高的多中心性乳腺癌比组织学分级低的ER蛋白的表达率低,但差别不具有统计学意义(P>0.05)。结论:ER、PR的检测除可以指导临床用药外,尚具有评估乳腺癌预后的作用。HER-2、Ki67、Nm23可能与多中心性乳腺癌发病有关,并可能成为多中心性乳腺癌的高危预测因子。Objective：To approach the expressions and significances of estrogen receptor（ER）,progesterone recetor（PR）,human epidermal growth factor receptor-2（HER-2）,Ki67,Nm23 and P53 in multicentric breast cancer.Methods：Clinical and pathological data of 45 cases of multicentric breast cancer from 2005 to 2010 in the affiliated tumor hospital of Xinjiang medical university were studied retrospectively and 60 cases unilateral single breast cancer were selected as the control.Results：①The positive rates of HER2 and Ki67 were higher in multicentric breast cancer than in unilateral single breast cancer,with significant differences（P〈0.05）.T he positive rate of Nm23 was lower in multicentric breast cancer than in unilateral single breast cancer,with significant differences（P〈0.05）.The positive rates of ER,PR and P53 were lower in multicentric breast cancer than in unilateral single breast cancer,with significant differences（P 〉0.05）.② The differences in the expression of ER,PR,HER-2,Ki67,Nm23 and P53 between special and non special multicentric breast cancer were insignificant（P 〉0.05）.③The expression of PR was lower in multicentric breast cancer with high histological differentiation than in those with low histological differentiation,with significant differences（P 〈0.05）.The ER protein expression was lower in multicentric breast cancer with high histological differentiation than in those with low histological differentiation,with significant differences（P 〉0.05）.Conclusions：The detection of ER and PR can not only guide the clinical drug administration but also indicate the progression of breast cancer.HER-2,Ki67 and Nm23 may be related with multicentric breast cancer,which may be high-risk factors of multicentric breast cancer.

关 键 词：多中心性乳腺癌 单侧单发乳腺癌 病理诊断学 

分 类 号：R737.9[医药卫生—肿瘤]